CTCFL

CTCFL
Identifikatori
Aliasi	CTCFL
Vanjski ID-jevi	OMIM: 607022 MGI: 3652571 HomoloGene: 46476 GeneCards: CTCFL
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	172,961,318 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • sequence-specific DNA binding; • GO:0031493 histone binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • vezivanje iona metala; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • citoplazma;
Biološki proces	• regulation of gene expression by genetic imprinting; • GO:0009373 regulation of transcription, DNA-templated; • regulation of histone H3-K4 methylation; • DNA methylation involved in gamete generation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:1901313 positive regulation of gene expression; • ćelijski ciklus; • Metilacija histona; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	140690
	664799
	n/a
	ENSMUSG00000070495
	Q8NI51
	A2APF3
NM_001269040; NM_001269041; NM_001269042; NM_001269043; NM_001269044;
	NM_001269045; NM_001269046; NM_001269047; NM_001269048; NM_001269049; NM_001269050; NM_001269051; NM_001269052; NM_001269054; NM_001269055; NM_080618; NM_001386993; NM_001386994; NM_001386995; NM_001386996; NM_001386997
	NM_001081387; NM_001355185
NP_001255969; NP_001255970; NP_001255971; NP_001255972; NP_001255973;
	NP_001255974; NP_001255975; NP_001255976; NP_001255977; NP_001255978; NP_001255979; NP_001255980; NP_001255981; NP_001255983; NP_001255984; NP_542185
	NP_001074856; NP_001342114
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transkripcijski represor CTCFL, znan i kao BORIS (brat regulatora imprintiranih mjesta) je protein koji je kod ljudi kodiran genom CTCFL.^[4]

Funkcija

CCCTC-vezujući faktor (CTCF), faktor 11–cinkovog prsta uključen u regulaciju gena, koristi različite cinkove prste da veže različita ciljna mjesta DNK. CTCF formira izolatore osjetljive na metilaciju, koji reguliraju Inaktivaciju X-hromosoma. Transkripcijski potiskivač CTCFL (ovaj protein) je paralog CTCF-a i čini se da se prvenstveno eksprimira u citoplazmi spermatocit a, za razliku od CTCF-a, koji se primarno ispoljava u jedru somatskih ćelija. CTCF i CTCFL obično se izražavaju u međusobno isključivom obrascu, koji korelira sa resetiranjem oznaka metilacije tokom diferencijacije muških klicinih ćelija.^[4]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070495 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CTCFL CCCTC-binding factor (zinc finger protein)-like".

Dopunska literatura

Klenova EM, Morse HC, Ohlsson R, Lobanenkov VV (2003). "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer". Semin. Cancer Biol. 12 (5): 399–414. doi:10.1016/S1044-579X(02)00060-3. PMID 12191639.
D'Arcy V, Pore N, Docquier F, et al. (2008). "BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours". Br. J. Cancer. 98 (3): 571–9. doi:10.1038/sj.bjc.6604181. PMC 2243163. PMID 18195709.
Woloszynska-Read A, James SR, Link PA, et al. (2008). "DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer". Cancer Immun. 7: 21. PMC 2935752. PMID 18095639.
Renaud S, Pugacheva EM, Delgado MD, et al. (2008). "Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors". Nucleic Acids Res. 35 (21): 7372–88. doi:10.1093/nar/gkm896. PMC 2175345. PMID 17962299.
Kholmanskikh O, Loriot A, Brasseur F, et al. (2008). "Expression of BORIS in melanoma: lack of association with MAGE-A1 activation". Int. J. Cancer. 122 (4): 777–84. doi:10.1002/ijc.23140. PMID 17957795.
Risinger JI, Chandramouli GV, Maxwell GL, et al. (2007). "Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression". Clin. Cancer Res. 13 (6): 1713–9. doi:10.1158/1078-0432.CCR-05-2569. PMID 17363524.
D'Arcy V, Abdullaev ZK, Pore N, et al. (2006). "The potential of BORIS detected in the leukocytes of breast cancer patients as an early marker of tumorigenesis". Clin. Cancer Res. 12 (20 Pt 1): 5978–86. doi:10.1158/1078-0432.CCR-05-2731. PMID 17062669.
Hoffmann MJ, Müller M, Engers R, Schulz WA (2007). "Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies". Biochem. Pharmacol. 72 (11): 1577–88. doi:10.1016/j.bcp.2006.06.020. PMID 16854382.
Hong JA, Kang Y, Abdullaev Z, et al. (2005). "Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells". Cancer Res. 65 (17): 7763–74. doi:10.1158/0008-5472.CAN-05-0823. PMID 16140944.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Loukinov DI, Pugacheva E, Vatolin S, et al. (2002). "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6806–11. doi:10.1073/pnas.092123699. PMC 124484. PMID 12011441.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

Vanjski linkovi

FactorBook CTCFL
Lokacija ljudskog genoma CTCFL i stranica sa detaljima o genu CTCFL u UCSC Genome Browseru.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000070495 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CTCFL CCCTC-binding factor (zinc finger protein)-like".

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