RPS4X

RPS4X
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4UG0, 4V6X, 5A2Q, 3J7R, 3J7P
Identifikatori
Aliasi	RPS4X
Vanjski ID-jevi	OMIM: 312760 MGI: 98158 HomoloGene: 90857 GeneCards: RPS4X
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	72,277,248 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	101,233,000 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• rRNA binding; • structural constituent of ribosome; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• citoplazma; • polysome; • citosol; • ribozom; • membrana; • focal adhesion; • intracellular anatomical structure; • cytosolic small ribosomal subunit; • small ribosomal subunit; • cytoplasmic ribonucleoprotein granule; • Egzosom; • GO:0005578 Vanćelijski matriks; • nukleoplazma; • ribonukleoprotein; • sinapsa;
Biološki proces	• viral transcription; • positive regulation of translation; • SRP-dependent cotranslational protein targeting to membrane; • multicellular organism development; • positive regulation of cell population proliferation; • translational initiation; • Nonsens-posredovano propadanje iRNK; • rRNA processing; • Biosinteza bjelančevina;
	Izvori:Amigo / QuickGO
Ortolozi
	6191
	20102
	ENSG00000198034
	ENSMUSG00000031320
	P62701
	P62702
	NM_001007
	NM_009094
	NP_000998
	NP_033120
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

X-izoforma 40S ribosomskog proteina S4 je protein koji je kod ljudi kodiran genom RPS4X.^[5]^[6]^[7]

Ribosomi, organele koje [kataliziraju sintezu proteina sastoje se od male 40S podjedinice i velike 60S podjedinice. Zajedno, ove podjedinice sastoje se od četiri tipa molekula RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein S4, komponentu 40S podjedinice. Ribosomski protein S4 jedini je ribosomski protein za koji je poznato da ga kodira više od jednog gena: ovaj gen i onaj za ribosomski protein S4, Y-vezani (RPS4Y). Dvije izoforme koje kodiraju ovi geni nisu identične, ali su funkcijski ekvivalenti. Ribosomski protein S4 pripada porodici ribosomskih proteina S4E. Ovaj gen nije podložan X-inaktivaciji. Sugerira se da haploinsuficijencija gena ribosomskog proteina S4 ima ulogu u pojavi Turnerovog sindroma; međutim, ova hipoteza pokazala se kao kontroverzna. Kao što je uobičajreno za gene koji kodiraju ribosomske proteine, postoji više obrađenih pseudogena ovog gena raspršenih širom genoma.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198034 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031320 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe M, Furuno N, Goebl M, Go M, Miyauchi K, Sekiguchi T, Basilico C, Nishimito T (Apr 1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene". J Cell Sci. 100 (1): 35–43. PMID 1795030.
^ Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC (Apr 1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol Cell Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC 358616. PMID 8139551.
^ ^a ^b "Entrez Gene: RPS4X ribosomal protein S4, X-linked".

Dopunska literatura

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID 8722009.
Fisher EM; Beer-Romero P; Brown LG; et al. (1991). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–1218. doi:10.1016/0092-8674(90)90416-C. PMID 2124517.
Wiles MV, Alexander CM, Goodfellow PN (1988). "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening". Somat. Cell Mol. Genet. 14 (1): 31–39. doi:10.1007/BF01535047. PMID 2829364.
Matoba R; Okubo K; Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Watanabe M, Zinn AR, Page DC, Nishimoto T (1993). "Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome". Nat. Genet. 4 (3): 268–271. doi:10.1038/ng0793-268. PMID 8358435.
Geerkens C, Just W, Held KR, Vogel W (1996). "Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X". Hum. Genet. 97 (1): 39–44. doi:10.1007/bf00218830. PMID 8557258.
Vladimirov SN; Ivanov AV; Karpova GG; et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–149. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Omoe K, Endo A (1996). "Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs". Genomics. 31 (1): 44–50. doi:10.1006/geno.1996.0007. PMID 8808278.
Kenmochi N; Kawaguchi T; Rozen S; et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–230. doi:10.1006/geno.2000.6470. PMID 11401437.
Robinson RC; Turbedsky K; Kaiser DA; et al. (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–1684. doi:10.1126/science.1066333. PMID 11721045.
Andersen JS; Lyon CE; Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–396. doi:10.1093/molbev/msh027. PMID 14660691.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198034 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031320 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1795030-5] Watanabe M, Furuno N, Goebl M, Go M, Miyauchi K, Sekiguchi T, Basilico C, Nishimito T (Apr 1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene". J Cell Sci. 100 (1): 35–43. PMID 1795030.

[pmid8139551-6] Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC (Apr 1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol Cell Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC 358616. PMID 8139551.

[entrez-7] "Entrez Gene: RPS4X ribosomal protein S4, X-linked".

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