BPIFB4

BPIFB4
Identifikatori
Aliasi	BPIFB4
Vanjski ID-jevi	OMIM: 615718 MGI: 2685852 HomoloGene: 66971 GeneCards: BPIFB4
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	33,111,751 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	153,806,021 bp
Ortolozi
	149954
	381399
	ENSG00000186191
	ENSMUSG00000074665
	P59827
	A2BGH0
	NM_182519
	NM_001034875
	NP_872325
	NP_001030047
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

BPI nabor koji sadrži člana 4 porodicu B je protein koji kod ljudi kodiran genom BPIFB4.^[5]

BPIFB4 ima sličnost u sekvenci sa antimikrobnim peptidima koji vežu lipofilne supstrate i pružaju odbranu od od gram-negativnih bakterija.^[6]

Pretragom baze podataka o mirisnom epitelu EST za sekvence slične pacovskim Ry2g5, nakon čega slijedi PCR biblioteke cDNK ljudskog ]]fetus]]nog mozga, klonirali su BPIFB4, koji su nazvali RY2G5. Izvedeni protein s 575 aminokiselina ima područje bogato leucinom, dva konzervirana cisteina i tri konzervirana prolina. Dijeli 90% aminokiselinskog identiteta s 462-aminokiselinskim mišjim ortologom. Northern blot analiza 16 ljudskih tkiva otkrila je transkript RY2G5 od 2,2 kb samo u leukocitima periferne krvi. RT-PCR analiza 14 tkiva miša otkrila je ekspresiju Ry2g5 samo u mirisnom epitelu. Fluorescentno označeni ljudski RY2G5 eksprimiran je u distribuciji tačaka citoplazme u transficiranim HEK293 ćelijama. Utvrdiili su da gen BPIFB4 sadrži 15 kodirajućih egzona i obuhvata približno 28,8 kb.

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186191 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074665 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: BPI fold containing family B, member 4".
^ Andrault, J.-B., Gaillard, I., Giorgi, D., Rouquier, S. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. Genomics 82: 172-184, 2003. [PubMed: 12837268]

Dopunska literatura uredi

Bingle CD, Craven CJ (august 2003). "Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families". Biochemical Society Transactions. 31 (Pt 4): 806–9. doi:10.1042/bst0310806. PMID 12887310.
Andrault JB, Gaillard I, Giorgi D, Rouquier S (august 2003). "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides". Genomics. 82 (2): 172–84. doi:10.1016/S0888-7543(03)00102-2. PMID 12837268.
Bingle CD, Seal RL, Craven CJ (august 2011). "Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily". Biochemical Society Transactions. 39 (4): 977–83. doi:10.1042/BST0390977. PMC 3196848. PMID 21787333.
Bingle CD, Craven CJ (april 2002). "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx". Human Molecular Genetics. 11 (8): 937–43. doi:10.1093/hmg/11.8.937. PMID 11971875.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186191 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074665 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BPI fold containing family B, member 4".

[6] Andrault, J.-B., Gaillard, I., Giorgi, D., Rouquier, S. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. Genomics 82: 172-184, 2003. [PubMed: 12837268]

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