UTY
Histonska demetilaza UTY je enzim koji je kod ljudi kodiran genom UTY.[3][4][5]
Ovaj gen kodira protein koji sadrži tetratrikopeptid-ponavljanje za koji se smatra da je uključen u interakcije protein-protein. Manji je antigen histokompatibilnost, koji može inducirati odbacivanje transplantata presađenih muških matičnih ćelija. Alternativna prerada RNK rezultira u više varijanti transkripta koji kodiraju različite izoforme.[5]
Interakcije
urediPokazano je da UTY ima interakcije sa TLE1 [6] i WDR90.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000183878 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (decembar 1996). "An H-YDb epitope is encoded by a novel mouse y chromosome gene". nature genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.
- ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (april 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
- ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
- ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (januar 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
- ^ "STRING: functional protein association networks". string-db.org. Pristupljeno 7. 5. 2015.
Dopunska literatura
uredi- Lahn BT, Page DC (oktobar 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
- Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (januar 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
- Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (mart 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
- Foresta C, Ferlin A, Moro E (maj 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
- Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (juni 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
- Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (novembar 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. PMID 11049993.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (maj 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Agate RJ, Choe M, Arnold AP (februar 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
- Gerrard DT, Filatov DA (juni 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.