Tireostimulirajući hormon beta

Tirostimulirajući hormon beta, skraćeno TSHB, je protein čiju sintezu, kod čovjeka kodira gen TSHB.

Tireostimulirajući hormon beta
Identifikatori
Aliasi	TSHB
Vanjski ID-jevi	OMIM: 188540 MGI: 98848 HomoloGene: 463 GeneCards: TSHB
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1p13.2 Početak 115,029,826 bp Kraj 115,034,302 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3 F2.2|3 45.25 cM Početak 102,682,781 bp Kraj 102,690,034 bp
Ontologija gena Molekularna funkcija • hormone activity Ćelijska komponenta • extracellular region • Vanćelijsko • citoplazma Biološki proces • response to calcium ion • cell-cell signaling • anatomical structure morphogenesis • G protein-coupled receptor signaling pathway • response to vitamin A • peptide hormone processing • response to estrogen • hormone-mediated signaling pathway • regulation of signaling receptor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7252	22094
Ensembl	ENSG00000134200	ENSMUSG00000027857
UniProt	P01222	P12656
RefSeq (mRNK)	NM_000549 NM_001277991	NM_001165939 NM_001165940 NM_009432
RefSeq (bjelančevina)	NP_000540 NP_001264920	NP_001159411 NP_001159412 NP_033458
Lokacija (UCSC)	Chr 1: 115.03 – 115.03 Mb	Chr 3: 102.68 – 102.69 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Tireostimulirajući hormon beta
Identifikatori
Simbol	TSHB
NCBI gen	7252
HGNC	12372
OMIM	188540
RefSeq	NM_000549
UniProt	P01222
Ostali podaci
Lokus	Hrom. 1 p13
Pretraga za Strukture Swiss-model Domene InterPro

Kod čovjeka, genski lokus TSHB je na kratkom (p) kraku hromosomu 1.

Funkcija

Tirostimulirajući hormon beta (TSH) je nekovalentno vezani glikoproteinski heterodimer, dio porodice hormona hipofize koji sadrže zajedničku alfa podjedinicu (TSHA), a specifičnost mu daje jedinstvena beta podjedinica (ovaj protein).

Također pogledajte

• Tireostimulirajući hormon

Dopunska literatura

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• Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brumm H, Pfeufer A, Biebermann H, et al. (2002). "Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect". J. Clin. Endocrinol. Metab. 87 (10): 4811–6. doi:10.1210/jc.2002-020297. PMID 12364478.
• Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). "Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death". Eur. J. Endocrinol. 160 (6): 985–91. doi:10.1530/EJE-08-0953. PMID 19273570.
• Schaefer JS, Klein JR (2009). "A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid". Gen. Comp. Endocrinol. 162 (3): 241–4. doi:10.1016/j.ygcen.2009.04.006. PMC 2689139. PMID 19364510.

Vanjski linkovi

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