Receptor koštanomorfogenetskog proteina
Recptori koštanomorfogenetskog proteina su serin-treonin-kinazni receptori. Za ove receptore vezuju se proteini poridice transformirajućih faktora rasta beta.[1] There are four bone morphogenetic protein receptors:[2]
| Porodica TKL Ser/Thr protein-kinaza | |
|---|---|
 Protein ACAVR1B | |
| Identifikatori | |
| Simbol | TKL |
Struktura
urediI koštanomorfogenetski proteinski receptori tipa 1 i 2 imaju jedan transmembranski segment. Dodatno, oba tipa imaju vanćelijkski domen bogat cisteinom i domenu citoplazmatske serin-treonin kinaze.[3] Tip 1 sadrži domen bogat glicinom-serinom koju treba fosforilirati domenom kinaze tipa 2, inicirajući put transdukcije signala SMAD signalne kaskade.[3] Zglob Motiv epitopa na BMP-2 ima vezno mjesto visokog afiniteta za BMPR-IA. Motiv epitopa zgloba na BMP-2 ima vezu niskog afiniteta za BMPR-II.[4]
Također pogledajte
urediReference
uredi- ^ Miyazono K, Kamiya Y, Morikawa M (januar 2010). "Bone morphogenetic protein receptors and signal transduction". Journal of Biochemistry. 147 (1): 35–51. doi:10.1093/jb/mvp148. PMID 19762341.
- ^ Pasche B (decembar 2008). "The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008". The Quarterly Review of Biology. 83 (4): 405–405. doi:10.1086/596254.
- ^ a b Mace PD, Cutfield JF, Cutfield SM (decembar 2006). "High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding". Biochemical and Biophysical Research Communications. 351 (4): 831–8. doi:10.1016/j.bbrc.2006.10.109. PMID 17094948.
- ^ Miyazono K, Shimanuki T (januar 2008). "Chapter 55: Bone morphogenetic protein receptors and actions.". u Bilezikian JP, Raisz LG, Martin TJ (ured.). Principles of bone biology (Third izd.). San Diego: Academic Press. str. 1177–1196. doi:10.1016/B978-0-12-373884-4.00069-0. ISBN 978-0-12-373884-4.
Vanjski linkovi
uredi- Bone Morphogenetic Protein Receptors na US National Library of Medicine Medical Subject Headings (MeSH)
