RRAGB
Ras-srodni GTP-vezulući protein B je protein koji je kod ljudi kodiran genom RRAGB.[4][5][6]
Ras-homologne GTPaze čine veliku porodicu pretvarača signala koji se izmjenjuju između aktiviranog, GTP-vezujućeg i inaktiviranog, GDP-vezujućeg stanja. Ti proteini predstavljaju ćelijske preklopnike kojima upravljaju faktori GTP-razmjene i faktori koji stimuliraju njihovu unutrašnju aktivnost GTPaza. Svim GTPazama superporodice Ras zajedničko je prisustvo šest konzerviranih motiva, uključenih u vezanje GTP/GDP, od kojih su tri mjesta za vezanje fosfata/magnezija (PM1-PM3) i od kojih su tri guaninska mjesta za vezanje nukleotida (G1-G3). Utvrđene su varijante transkripta koje kodiraju različite izoforme. MTORC1 reaguje na aminokiseline, interakcijom sa RAGB.[6]
Reference uredi
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041658 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
- ^ Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. PMID 9394008.
- ^ a b "Entrez Gene: RRAGB Ras-related GTP binding B".
Dopunska literatura uredi
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.