PRKY

PRKY
Identifikatori
Aliasi	PRKY
Vanjski ID-jevi	OMIM: 400008 GeneCards: PRKY
Lokacija gena (čovjek)
Hrom.	Hromosom Y
Kraj	7,381,548 bp
Ortolozi
	5616
	n/a
	ENSG00000099725
	n/a
	n; a
	n/a
	NM_002760
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Serin/treonin-protein kinaza PRKY je enzim koji je kod čovjeka kodiran genom PRKY.^[3]^[4] Ovaj gen kodira člana porodice cAMP-ovisnu serin/treonin protein kinazu. Ovaj gen se nalazi na hromozomu Y, blizu granice pseudoautosomne regije. Abnormalna rekombinacija između ovog gena i srodnog gena na hromozomu X čest je uzrok XX muškaraca i XY žene.^[4]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099725 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G (Sep 1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. 4 (5): 869–78. doi:10.1093/hmg/4.5.869. PMID 7633447.
^ ^a ^b "Entrez Gene: PRKY protein kinase, Y-linked".

Dopunska literatura uredi

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jobling MA, Williams GA, Schiebel GA, et al. (1999). "A selective difference between human Y-chromosomal DNA haplotypes". Curr. Biol. 8 (25): 1391–4. doi:10.1016/S0960-9822(98)00020-7. PMID 9889101.
Schiebel K, Winkelmann M, Mertz A, et al. (1998). "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females". Hum. Mol. Genet. 6 (11): 1985–9. doi:10.1093/hmg/6.11.1985. PMID 9302280.
Schiebel K, Mertz A, Winkelmann M, et al. (1997). "FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12→q13". Cytogenet. Cell Genet. 76 (1–2): 49–52. doi:10.1159/000134514. PMID 9154127.
Gläser B, Hierl T, Taylor K, et al. (1997). "High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin". Chromosome Res. 5 (1): 23–30. doi:10.1023/A:1018437301461. PMID 9088640.

Vanjski linkovi uredi

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099725 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7633447-3] Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G (Sep 1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. 4 (5): 869–78. doi:10.1093/hmg/4.5.869. PMID 7633447.

[entrez-4] "Entrez Gene: PRKY protein kinase, Y-linked".

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