NRK

(Preusmjereno sa NESK)

Nik-srodna protein-kinaza je enzim koji je kod ljudi kodiran genom NRK.^[5]

NRK

Identifikatori

Vanjski ID-jevi

OMIM: 300791 MGI: 1351326 HomoloGene: 8442 GeneCards: NRK

Lokacija gena (čovjek)

Hrom.	Hromosom X^[1]

Bend	Xq22.3	Početak	105,822,539 bp^[1]
Bend	Xq22.3	Kraj	105,958,610 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom X (miš)^[2]

Bend	X F1\|X 61.15 cM	Početak	137,815,179 bp^[2]
Bend	X F1\|X 61.15 cM	Kraj	137,911,281 bp^[2]

Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom • nucleotide binding • protein kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • MAP kinase kinase kinase kinase activity
Ćelijska komponenta	• citoplazma
Biološki proces	• protein phosphorylation • regulation of spongiotrophoblast cell proliferation • rođenje • Fosforilacija • negative regulation of cell population proliferation • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • regulation of apoptotic process • neuron projection morphogenesis • MAPK cascade • GO:0072468 Transdukcija signala • actin cytoskeleton reorganization • activation of protein kinase activity
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


203447


27206


ENSG00000123572


ENSMUSG00000052854


Q7Z2Y5


Q9R0G8

RefSeq (mRNK)


NM_198465


NM_013724

RefSeq (bjelančevina)


NP_940867


NP_038752

Lokacija (UCSC)

Chr X: 105.82 – 105.96 Mb

Chr X: 137.82 – 137.91 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123572 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052854 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NRK Nik related kinase".

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakano K, Kanai-Azuma M, Kanai Y, et al. (2003). "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family". Exp. Cell Res. 287 (2): 219–27. doi:10.1016/S0014-4827(03)00136-8. PMID 12837278.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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