MIR7-1

MikroRNK 7-1 je mikroRNK molekula koja je kodirana genom MIR7-1.

MIR7-1
Identifikatori
Aliasi	MIR7-1
Vanjski ID-jevi	OMIM: 615239 GeneCards: MIR7-1
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q21.32 Početak 83,969,748 bp Kraj 83,969,857 bp
Ortolozi
Vrste	Čovjek	Miš
Entrez	407043	n/a
Ensembl	ENSG00000284179	n/a
UniProt	n a	n/a
RefSeq (mRNK)	n/a	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	Chr 9: 83.97 – 83.97 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Funkcija

mikroRNK ili miRNA su kratke (20-24 nukleotidne) nekodirajuće RNK koje su uključene u post-transkripcijsku regulaciju ekspresije gena u višećelijskih organizama utičući i na stabilnost i na translaciju iRNK. miRNK se transkribiraju RNK-polimerazom II kao dio pokrivenih i poliadeniliranih primarnih transkripata (pre-miRNK) koje mogu biti protein-kodirajuće ili nekodirajuće. Primarni transkript cijepa enzim Drosha ribonukleaza III, da bi se proizvela približno 70-nt prekursorna miRNK iz matične petlje (pre-miRNK), koju dalje cijepa citoplazmatska Dicer ribonukleaza, kako bi nastali proizvodi zrela miRNK i antisens miRNK zvjezdica (miRNK*). Zrela miRNK je inkorporirana u RNK-inducirani kompleks za utišavanje (RISC), koji prepoznaje ciljane iRNK, putem nesavršenog uparivanja baza s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljane iRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK (obezbedio RefSeq, septembar 2009).

Dopunska literatura

• Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (mart 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. S2CID 37750545.
• Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (april 2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns. 9 (4): 193–9. doi:10.1016/j.gep.2008.12.003. PMID 19135553.
• Chen AX, Yu KD, Fan L, Li JY, Yang C, Huang AJ, Shao ZM (septembar 2011). Horwitz MS (ured.). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS Genetics. 7 (9): e1002259. doi:10.1371/journal.pgen.1002259. PMC 3164678. PMID 21912531.
• Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T (januar 2013). "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway". Molecular Biology of the Cell. 24 (1): 42–55. doi:10.1091/mbc.E12-07-0519. PMC 3530778. PMID 23135998.
• Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B (maj 2008). "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research. 68 (10): 3566–72. doi:10.1158/0008-5472.CAN-07-6639. PMID 18483236.
• Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL (februar 2008). "Quantitative differential expression analysis reveals miR-7 as major islet microRNA". Biochemical and Biophysical Research Communications. 366 (4): 922–6. doi:10.1016/j.bbrc.2007.12.052. PMC 4104201. PMID 18086561.
• Chen ZX, Sun AM, Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW (august 2010). "[Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma]". Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University. 30 (8): 1810–2, 1816. PMID 20813671.
• Kredo-Russo S, Ness A, Mandelbaum AD, Walker MD, Hornstein E (2012). "Regulation of pancreatic microRNA-7 expression". Experimental Diabetes Research. 2012: 695214. doi:10.1155/2012/695214. PMC 3362837. PMID 22675342.
• Wang Y, Liu J, Liu C, Naji A, Stoffers DA (mart 2013). "MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells". Diabetes. 62 (3): 887–95. doi:10.2337/db12-0451. PMC 3581216. PMID 23223022.
• Midgley AC, Bowen T, Phillips AO, Steadman R (april 2014). "MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts". Aging Cell. 13 (2): 235–44. doi:10.1111/acel.12167. PMC 4331777. PMID 24134702.
• Midgley AC, Morris G, Phillips AO, Steadman R (juni 2016). "17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation". Aging Cell. 15 (3): 531–41. doi:10.1111/acel.12462. PMC 4854905. PMID 26931423.