OTUD5

OTUD5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3PFY, 3TMO, 3TMP
Identifikatori
Aliasi	OTUD5
Vanjski ID-jevi	OMIM: 300713 MGI: 1859615 HomoloGene: 136483 GeneCards: OTUD5
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	48,958,386 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	7,742,865 bp
Ontologija gena
Molekularna funkcija	• thiol-dependent deubiquitinase; • GO:0070122 peptidase activity; • cysteine-type peptidase activity; • hydrolase activity; • Lys63-specific deubiquitinase activity; • GO:1904265 deubiquitinase activity; • Lys48-specific deubiquitinase activity;
Ćelijska komponenta	• citosol;
Biološki proces	• negative regulation of type I interferon production; • response to lipopolysaccharide; • protein K63-linked deubiquitination; • protein K48-linked deubiquitination; • Proteoliza; • protein deubiquitination;
	Izvori:Amigo / QuickGO
Ortolozi
	55593
	54644
	ENSG00000068308
	ENSMUSG00000031154
	Q96G74
	Q3U2S4
	NM_001136157; NM_001136158; NM_001136159; NM_017602
	NM_001290536; NM_001290537; NM_138604
	NP_001129629; NP_001129630; NP_001129631; NP_060072
	NP_001277465; NP_001277466; NP_613070
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

OTU-deubikvitinaza 5 je enzimski protein koji je kod ljudi kodiran genom OTUD5. ^[5]

Funkcija

Ovaj gen kodira člana natporodice cisteinskih proteaze, koje sadrži domen OTU (tumor jajnika). OTU-domen imaa aktivnost deubikvitinaze, a pokazalo se da kodirani protein potiskuje urođeni imunski interferon-ovisni odgovor tipa I, cijepanjem lanca poliubikvitina od esencijalnog proteinskog adaptera interferona tipa I. Cijepanje rezultira razdvajanjem adapterskog proteina iz nizvodnog signalnog kompleksa i poremećajem signalne interferonske kaskade tipa I. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031154 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OTU deubiquitinase 5". Pristupljeno 25. 3. 2017.

Dopunska literatura

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). "DUBA: a deubiquitinase that regulates type I interferon production". Science. 318 (5856): 1628–32. doi:10.1126/science.1145918. PMID 17991829.
Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). "Phosphorylation-dependent activity of the deubiquitinase DUBA". Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969.
Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). "OTUD5 regulates p53 stability by deubiquitinating p53". PLoS ONE. 8 (10): e77682. doi:10.1371/journal.pone.0077682. PMC 3797110. PMID 24143256.

Vanjski linkovi

Q96G74

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031154 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OTU deubiquitinase 5". Pristupljeno 25. 3. 2017.

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