Katepsin H

CTSH
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1BZN
Identifikatori
Aliasi	CTSH, ACC-4, ACC-5, CPSB, minilanac, ACC4, ACC5, katepsin H
Vanjski ID-jevi	OMIM: 116820 MGI: 107285 HomoloGene: 36159 GeneCards: CTSH
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	78,949,574 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	89,958,142 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• peptidase activator activity involved in apoptotic process; • cysteine-type peptidase activity; • HLA-A specific activating MHC class I receptor activity; • endopeptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • cysteine-type endopeptidase activator activity involved in apoptotic process; • cysteine-type endopeptidase activity; • aminopeptidase activity; • serine-type endopeptidase activity; • hydrolase activity; • thyroid hormone binding; • GO:0070122 peptidase activity;
Ćelijska komponenta	• citosol; • alveolar lamellar body; • Lizozom; • Egzosom; • multivesicular body lumen; • extracellular region; • Vanćelijsko; • secretory granule lumen; • intracellular membrane-bounded organelle; • tertiary granule lumen; • ficolin-1-rich granule lumen; • cytoplasmic ribonucleoprotein granule; • collagen-containing extracellular matrix;
Biološki proces	• surfactant homeostasis; • antigen processing and presentation; • adaptive immune response; • bradykinin catabolic process; • response to retinoic acid; • membrane protein proteolysis; • positive regulation of cell migration; • ERK1 and ERK2 cascade; • zymogen activation; • neuropeptide catabolic process; • positive regulation of epithelial cell migration; • positive regulation of apoptotic signaling pathway; • negative regulation of apoptotic process; • Proteoliza; • positive regulation of angiogenesis; • positive regulation of peptidase activity; • GO:1901313 positive regulation of gene expression; • protein destabilization; • cellular response to thyroid hormone stimulus; • positive regulation of cell population proliferation; • immune response-regulating signaling pathway; • proteolysis involved in cellular protein catabolic process; • metanephros development; • dichotomous subdivision of terminal units involved in lung branching; • T cell mediated cytotoxicity; • GO:0097285 apoptoza; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • neutrophil degranulation;
	Izvori:Amigo / QuickGO
Ortolozi
	1512
	13036
	ENSG00000103811
	ENSMUSG00000032359
	P09668
	P49935
	NM_004390; NM_148979; NM_001319137
	NM_007801; NM_001312649
	NP_001306066; NP_004381
	NP_001299578; NP_031827
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Katepsin H – katepsin B3, benzoilarginin-naftilamidna hidrolaza (BANA), katepsin Ba, aleurain, N-benzoilarginin-beta-naftilamidna hidrolaza – je proteinski enzim EC 3.4.22.16 koji je kod ljudi kodiran sa gen CTSH.^[5]^[6]^[7]^[8]^[9]

Protein kojeg kodira ovaj gen je lizosomna cistein proteinaza, važna u ukupnom razlaganju lizosomnih proteina. Sastoji se od dimera od disulfidno-povezanih teških i lahkih lanaca, oba proizvedena iz jednog prekursorskog proteina. Kodirani protein, koji pripada proteinskoj porodici peptidaza C1, može djelovati i kao aminopeptidaza i kao endopeptidaza. Povećana ekspresija ovog gena je u korelaciji sa malignom progresijom tumora prostate. Dvije varijante transkripta kodirane su iz različitih izoformi ovog gena.^[10]^[11]^[12]

Također pogledajte uredi

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103811 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032359 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.
^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
^ Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.
^ Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.
^ Barrett, A.J. and Kirschke, H. (1981). "Cathepsin B, cathepsin H and cathepsin L". Methods Enzymol. 80: 535–561. PMID 7043200.CS1 održavanje: više imena: authors list (link)
^ Brömme, D., Bescherer, K., Kirschke, H. and Fittkau, S. (1987). "Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver". Biochem. J. 245: 381–385. PMID 3663163.CS1 održavanje: više imena: authors list (link)
^ Fuchs, R., Machleidt, W. and Gassen, H.G. (1988). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol. Chem. Hoppe-Seyler. 369: 469–475. PMID 2849458.CS1 održavanje: više imena: authors list (link)

Vanjski linkovi uredi

Cathepsin na Wikimedia Commonsu.

Cathepsin H na Wikimedia Commonsu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103811 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032359 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.

[6] Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.

[7] Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.

[8] Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.

[9] Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.

[10] Barrett, A.J. and Kirschke, H. (1981). "Cathepsin B, cathepsin H and cathepsin L". Methods Enzymol. 80: 535–561. PMID 7043200.CS1 održavanje: više imena: authors list (link)

[11] Brömme, D., Bescherer, K., Kirschke, H. and Fittkau, S. (1987). "Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver". Biochem. J. 245: 381–385. PMID 3663163.CS1 održavanje: više imena: authors list (link)

[12] Fuchs, R., Machleidt, W. and Gassen, H.G. (1988). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol. Chem. Hoppe-Seyler. 369: 469–475. PMID 2849458.CS1 održavanje: više imena: authors list (link)

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