SEMA7A

SEMA7A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3NVQ
Identifikatori
Aliasi	SEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaforin 7A (krvna grupa Johna Miltona Hagena)
Vanjski ID-jevi	OMIM: 607961 MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	74,433,958 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	57,870,148 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • integrin binding; • neuropilin binding; • semaphorin receptor binding; • chemorepellent activity;
Ćelijska komponenta	• membrana; • ćelijska membrana; • anchored component of membrane; • Vanćelijsko; • external side of plasma membrane; • integral component of plasma membrane; • collagen-containing extracellular matrix;
Biološki proces	• Ćelijska diferencijacija; • positive regulation of protein phosphorylation; • nervous system development; • multicellular organism development; • osteoblast differentiation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • axon extension; • olfactory lobe development; • integrin-mediated signaling pathway; • positive regulation of axon extension; • inflammatory response; • neuron projection development; • regulation of inflammatory response; • negative chemotaxis; • positive regulation of macrophage cytokine production; • neural crest cell migration; • positive regulation of cell migration; • negative regulation of axon extension involved in axon guidance; • semaphorin-plexin signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	8482
	20361
	ENSG00000138623; ENSG00000288455
	ENSMUSG00000038264
	O75326
	Q9QUR8
	NM_003612; NM_001146029; NM_001146030
	NM_011352
	NP_001139501; NP_001139502; NP_003603
	NP_035482
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nekadašnji naziv John Milton Hagen sistem antigena (Milton Hagen krvna grupa), prema najnovijoj nomenklaturi je preimenovan u Semaforin 7A, GPI membransko sidro (SEMA7A), poznat i kao CD108 (Cluster of Differentiation 108), je ljudski gen.^[5]

SEMA7A^[5] je membranski vezani semaforin na ćelijskim površinama, vezan preko glikozilfosfatidilinozitola (GPI). SEMA7A, tj. antigen krvne grupe Milton-Hagen (JMH), je glikoprotein od 80 kD, koji se ispoljava na aktiviranim limfocitima i eritrocitima.

Genetika

Ovaj protein ima osam varijanti u vanćelijskoj regiji: sedam leži unutarSema domene a jedan u domeni PSI.

Molekulska biologija

Ovaj protein formira dimere.

Napomena

Ovaj protein djeluje kao receptor malarijskog parazita Plasmodium falciparum.

Reference

^ ^a ^b ^c ENSG00000288455 GRCh38: Ensembl release 89: ENSG00000138623, ENSG00000288455 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038264 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

Također pogledajte

[refGRCh38Ensembl-1] ENSG00000288455 GRCh38: Ensembl release 89: ENSG00000138623, ENSG00000288455 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038264 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

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