ZNF182

ZNF182
Identifikatori
Aliasi	ZNF182
Vanjski ID-jevi	OMIM: 314993 MGI: 2442220 HomoloGene: 45884 GeneCards: ZNF182
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	48,003,989 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	21,062,316 bp
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7569
	319535
	ENSG00000147118
	ENSMUSG00000054737
	P17025
	Q6P560
	NM_006962; NM_001007088; NM_001178099
	NM_001013387; NM_001111076
	NP_001007089; NP_001171570; NP_008893
	NP_001013405; NP_001104546
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta 182 jest protein koji je kod ljudi kodiran genom ZNF182.^[5]^[6]^[7]^[8]

Modelni organizmi

U proučavanju funkcije ZNF182 korišteni su modelni organizmi. Uvjetna linija nokaut miša zvana Zfp182^{tm1b(KOMP) Wtsi} generirana je u Wellcome Trust Sanger Institute.^[9] Kako bi se utvrdili efekti delecije, muške i ženske životinje prolazile su standardizirano fenotipski snimanje^[10]^[11]^[12]^[13]^[14] Izvršeni su dodatni pregledi: Dubinsko imunosko fenotipiziranje ^[15] – dubinskim fenotipiziranjem kostiju i hrskavice.^[16]

*Zfp182* fenotip nokaut-miša
Svojstvo	Fenotip
Svi podaci raspoloživi na linkuAll data available at.^[10]^[15]^[16]
Leukociti periferne krvi od 6 sedmica	Normalni
Hematologija 6 sedmica	Normalna
Insulin	Normalan
Homozigotna varijabilnost P14	Normalna
Homozigotna plodnost	Normalna
Tjelesna težina	Normalna
Nervni snimak	Normalan
Snaga prianjanja	Normalna
Dismorfologija	Normalna
Indirektna kalorimetrija	Normalna
Test tolerancije glukoze	Normalan
Slušni odgovor moždanog debla	Normalan
DEXA-a	Normalna
Radiografija	Normalna
Morfologija oka	Normalna
Klinička hemija	Normalna
Hematologija 16 sedmica	Normalna
Leukociti periferne krvi 16 sedmica	Normalni
Težina srca	Normalna
Infekcija bakterijom Salmonella	Normalna
Citotoksična funkcija T-ćelija	Normalna
Imunofenotipizacija slezene	Normalna
Imunofenotipizacija mezenterskih limfnih čvorova	Normalni
Imunofenotipizacija koštane srži	Normalna
Epidermni imunski sastav	Normalan
Izazov gripe	Normalan
Izazov Trichuris-a	Normalan

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147118 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054737 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Knight JC, Grimaldi G, Thiesen HJ, Bech-Hansen NT, Fletcher CD, Coleman MP (maj 1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
^ Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
^ Wang R, Cukerman E, Heng HH, Liew CC (maj 1996). "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics. 22 (3): 237–9. doi:10.1007/BF02369914. PMID 8914609.
^ "Entrez Gene: ZNF182 zinc finger protein 182".
^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
^ ^a ^b "International Mouse Phenotyping Consortium".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
^ ^a ^b "Infection and Immunity Immunophenotyping (3i) Consortium". Arhivirano s originala, 21. 5. 2015. Pristupljeno 1. 4. 2021.
^ ^a ^b "Potrošnja OBCD". Arhivirano s originala, 12. 8. 2020. Pristupljeno 1. 4. 2021.

Dopunska literatura

Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147118 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054737 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8088786-5] Knight JC, Grimaldi G, Thiesen HJ, Bech-Hansen NT, Fletcher CD, Coleman MP (maj 1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.

[pmid2014798-6] Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.

[pmid8914609-7] Wang R, Cukerman E, Heng HH, Liew CC (maj 1996). "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics. 22 (3): 237–9. doi:10.1007/BF02369914. PMID 8914609.

[entrez-8] "Entrez Gene: ZNF182 zinc finger protein 182".

[mgp_reference-9] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.

[IMPCsearch_ref-10] "International Mouse Phenotyping Consortium".

[pmid21677750-11] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-12] Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-13] Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.

[pmid23870131-14] White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.

[iii_ref-15] "Infection and Immunity Immunophenotyping (3i) Consortium". Arhivirano s originala, 21. 5. 2015. Pristupljeno 1. 4. 2021.

[obcd_ref-16] "Potrošnja OBCD". Arhivirano s originala, 12. 8. 2020. Pristupljeno 1. 4. 2021.

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