PIN4

PIN4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1EQ3, 1FJD, 3UI4, 3UI5, 3UI6
Identifikatori
Aliasi	PIN4
Vanjski ID-jevi	OMIM: 300252 MGI: 1916963 HomoloGene: 121907 GeneCards: PIN4
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	72,302,926 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	102,127,669 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • double-stranded DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • bent DNA binding; • isomerase activity; • peptidyl-prolyl cis-trans isomerase activity; • vezivanje sa RNK;
Ćelijska komponenta	• citoplazma; • mitochondrial matrix; • Diobeno vreteno; • preribosome; • Jedarce; • Egzosom; • citoskelet; • mitohondrija; • jedro;
Biološki proces	• rRNA processing; • protein peptidyl-prolyl isomerization;
	Izvori:Amigo / QuickGO
Ortolozi
	5303
	69713
	ENSG00000102309
	ENSMUSG00000079480
	Q9Y237
	Q9CWW6
	NM_001170747; NM_006223
	NM_027181
	NP_001164218; NP_006214
	NP_081457; NP_001352019
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Peptidil-prolil cis-trans NIMA-interaktivna izomeraza 4 je enzim koji je kod ljudi kodiran genom PIN4.^[5]^[6]^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102309 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079480 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7: 9. doi:10.1186/1471-2199-7-9. PMC 1420321. PMID 16522211.
^ Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5: 37. doi:10.1186/1741-7007-5-37. PMC 2031878. PMID 17875217.
^ "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

Dopunska literatura

Uchida T, Fujimori F, Tradler T, et al. (1999). "Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase". FEBS Lett. 446 (2–3): 278–82. doi:10.1016/S0014-5793(99)00239-2. PMID 10100858.
Rulten S, Thorpe J, Kay J (1999). "Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases". Biochem. Biophys. Res. Commun. 259 (3): 557–62. doi:10.1006/bbrc.1999.0828. PMID 10364457.
Sekerina E, Rahfeld JU, Müller J, et al. (2000). "NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein". J. Mol. Biol. 301 (4): 1003–17. doi:10.1006/jmbi.2000.4013. PMID 10966801.
Terada T, Shirouzu M, Fukumori Y, et al. (2001). "Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14". J. Mol. Biol. 305 (4): 917–26. doi:10.1006/jmbi.2000.4293. PMID 11162102.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Fujiyama S, Yanagida M, Hayano T, et al. (2002). "Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes". J. Biol. Chem. 277 (26): 23773–80. doi:10.1074/jbc.M201181200. PMID 11960984.
Surmacz TA, Bayer E, Rahfeld JU, et al. (2002). "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding". J. Mol. Biol. 321 (2): 235–47. doi:10.1016/S0022-2836(02)00615-0. PMID 12144781.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102309 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079480 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16522211-5] Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7: 9. doi:10.1186/1471-2199-7-9. PMC 1420321. PMID 16522211.

[pmid17875217-6] Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5: 37. doi:10.1186/1741-7007-5-37. PMC 2031878. PMID 17875217.

[entrez-7] "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

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