EMILIN1

Interfejser-1 elastinskih mikrofibrila (EMILIN-1) je protein koji je kod ljudi kodiran sa genskog lokusa EMILIN1. To je najbolje opisani član porodice EMILIN glikoproteina vanćelijskog matriksa.

EMILIN1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2KA3, 2OII
Identifikatori
Aliasi	EMILIN1
Vanjski ID-jevi	OMIM: 130660 MGI: 1926189 HomoloGene: 5117 GeneCards: EMILIN1
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2p23.3 Početak 27,078,615 bp Kraj 27,086,403 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 B1 Početak 31,070,746 bp Kraj 31,078,621 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • extracellular matrix constituent conferring elasticity • vezivanje identičnih proteina • integrin binding involved in cell-matrix adhesion • extracellular matrix structural constituent Ćelijska komponenta • collagen • extracellular region • Egzosom • Vanćelijsko • GO:0005578 Vanćelijski matriks • integrin alpha4-beta1 complex • EMILIN complex • collagen-containing extracellular matrix Biološki proces • Ćelijska adhezija • cell-matrix adhesion • Ćelijska migracija • protein homotrimerization • aortic valve morphogenesis • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • positive regulation of cell-substrate adhesion • negative regulation of angiogenesis • extracellular matrix organization • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of collagen biosynthetic process • elastic fiber assembly • negative regulation of cell activation • negative regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of ERK1 and ERK2 cascade • positive regulation of extracellular matrix assembly • negative regulation of collagen fibril organization • negative regulation of macrophage migration Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11117	100952
Ensembl	ENSG00000138080	ENSMUSG00000029163
UniProt	Q9Y6C2	Q99K41
RefSeq (mRNK)	NM_007046	NM_133918
RefSeq (bjelančevina)	NP_008977	NP_598679
Lokacija (UCSC)	Chr 2: 27.08 – 27.09 Mb	Chr 5: 31.07 – 31.08 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Također pogledajte

• Vezivno tkivo

Dopunska literatura

• Mongiat M; Mungiguerra G; Bot S; et al. (2000). "Self-assembly and supramolecular organization of EMILIN". J. Biol. Chem. 275 (33): 25471–80. doi:10.1074/jbc.M001426200. PMID 10821830.
• Sterzel RB; Hartner A; Schlötzer-Schrehardt U; et al. (2000). "Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture". Kidney Int. 58 (4): 1588–602. doi:10.1046/j.1523-1755.2000.00320.x. PMID 11012893.
• Doliana R; Bot S; Mungiguerra G; et al. (2001). "Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily". J. Biol. Chem. 276 (15): 12003–11. doi:10.1074/jbc.M011591200. PMID 11278945.
• Spessotto P; Cervi M; Mucignat MT; et al. (2003). "beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain". J. Biol. Chem. 278 (8): 6160–7. doi:10.1074/jbc.M208322200. PMID 12456677.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Verdone G; Colebrooke SA; Boyd J; et al. (2004). "Sequence-specific backbone NMR assignments for the C-terminal globular domain of EMILIN-1". J. Biomol. NMR. 29 (1): 91–2. doi:10.1023/B:JNMR.0000019460.94913.6a. PMID 15017143.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L; Zhu YF; Guo XJ; et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519.
• Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.CS1 održavanje: upotreba parametra authors (link)
• Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.