CSTL1

Cistatinoliki protein 1 je protein koji je kod ljudi kodiran genom CSTL1. .

CSTL1
Identifikatori
Aliasi	CSTL1
Vanjski ID-jevi	MGI: 2652834 HomoloGene: 16283 GeneCards: CSTL1
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek) Bend 20p11.21 Početak 23,439,685 bp Kraj 23,444,930 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 G3 Početak 148,592,278 bp Kraj 148,597,353 bp
Ontologija gena Molekularna funkcija • peptidase inhibitor activity • protease binding • cysteine-type endopeptidase inhibitor activity Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of peptidase activity • negative regulation of cysteine-type endopeptidase activity • negative regulation of endopeptidase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	128817	228756
Ensembl	ENSG00000125823	ENSMUSG00000055177
UniProt	Q9H114	Q80Y72
RefSeq (mRNK)	NM_138283	NM_177655 NM_001362207
RefSeq (bjelančevina)	NP_612140	NP_808323 NP_001349136
Lokacija (UCSC)	Chr 20: 23.44 – 23.44 Mb	Chr 2: 148.59 – 148.6 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Superporodica cistatina obuhvata proteine koji sadrže višestruke sekvence slične cistatinu. Neki od članova su aktivni inhibitori cistein proteaza, dok su drugi izgubili ili možda nikada nisu stekli ovu inhibitornu aktivnost. U natporodici postoje tri porodice inhibitora, uključujući tip 1 cistatina (stefini), cistatini tipa 2 i kininogeni. Proteini cistatina tipa 2 su klasa inhibitora cistein-proteinaze koji se nalaze u raznim ljudskim tečnostima i sekretu. Lokus cistatina na hromosomu 20 sadrži većinu gena za cistatin tipa 2 i pseudogene. Ovaj gen nalazi se na telomernom kraju cistatinskog lokusa i kodira protein sličan cistatinu tipa 2. Specifična funkcija ovog proteina nije utvrđena.

Vanjski linkovi

• Lokacija ljudskog genoma CSTL1 i stranica sa detaljima o genu CSTL1 u UCSC Genome Browseru.

Dopunska literatura

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC 2143511. PMID 9007972.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID 8179826.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID 7896273.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID 7690606.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID 3202964.