Arhejska translacija

Arhejska translacija je proces kojim se informacijska RNK translatira u proteine u Archaea. Ne zna se mnogo o ovoj temi, ali na nivou proteina izgleda da liči na eukariotsku translaciju.

Izbor startnog kodona u inicijaciji erhejske translacije

Većina inicijacija, elongacija i faktora terminacije u arhejama imaju homologe u eukariotima.^[1] Shine-Dalgarnova sekvenca nalazi se samo u manjini gena za mnoge tipove, s mnogo iRNK bez vodećeg lanca vjerovatno pokrenutih skeniranjem.^[2]^[3]^[4] Proces ABCE1 recikliranja zasnovanog na ATPazama se također dijeli sa eukariotima.^[5]

Budući da su prokarioti bez jedra, arheje vrše transkripciju i translaciju u isto vrijeme kao i bakterije.^[6]

Reference

^ Saito K, Kobayashi K, Wada M, Kikuno I, Takusagawa A, Mochizuki M, et al. (novembar 2010). "Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (45): 19242–7. Bibcode:2010PNAS..10719242S. doi:10.1073/pnas.1009599107. PMC 2984191. PMID 20974926.
^ Hernández, Greco; Jagus, Rosemary (10. 8. 2016). "Evolution of Translational Initiation: From Archaea to Eukarya". Evolution of the protein synthesis machinery and its regulation. Hernández, Greco,, Jagus, Rosemary. Switzerland. doi:10.1007/978-3-319-39468-8_4. ISBN 9783319394688. OCLC 956539514.
^ Benelli, D; Londei, P (januar 2011). "Translation initiation in Archaea: conserved and domain-specific features". Biochemical Society Transactions. 39 (1): 89–93. doi:10.1042/BST0390089. PMID 21265752.
^ Nakagawa, S; Niimura, Y; Gojobori, T (20. 4. 2017). "Comparative genomic analysis of translation initiation mechanisms for genes lacking the Shine-Dalgarno sequence in prokaryotes". Nucleic Acids Research. 45 (7): 3922–3931. doi:10.1093/nar/gkx124. PMC 5397173. PMID 28334743.
^ Becker, T; Franckenberg, S; Wickles, S; Shoemaker, CJ; Anger, AM; Armache, JP; Sieber, H; Ungewickell, C; Berninghausen, O; Daberkow, I; Karcher, A; Thomm, M; Hopfner, KP; Green, R; Beckmann, R (22. 2. 2012). "Structural basis of highly conserved ribosome recycling in eukaryotes and archaea". Nature. 482 (7386): 501–6. Bibcode:2012Natur.482..501B. doi:10.1038/nature10829. PMC 6878762. PMID 22358840.
^ French, S. L.; Santangelo, T. J.; Beyer, A. L.; Reeve, J. N. (30. 1. 2007). "Transcription and Translation are Coupled in Archaea". Molecular Biology and Evolution. 24 (4): 893–895. doi:10.1093/molbev/msm007. PMID 17237472.

Vanjski linkovi

[1] Saito K, Kobayashi K, Wada M, Kikuno I, Takusagawa A, Mochizuki M, et al. (novembar 2010). "Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (45): 19242–7. Bibcode:2010PNAS..10719242S. doi:10.1073/pnas.1009599107. PMC 2984191. PMID 20974926.

[:0-2] Hernández, Greco; Jagus, Rosemary (10. 8. 2016). "Evolution of Translational Initiation: From Archaea to Eukarya". Evolution of the protein synthesis machinery and its regulation. Hernández, Greco,, Jagus, Rosemary. Switzerland. doi:10.1007/978-3-319-39468-8_4. ISBN 9783319394688. OCLC 956539514.

[pmid21265752-3] Benelli, D; Londei, P (januar 2011). "Translation initiation in Archaea: conserved and domain-specific features". Biochemical Society Transactions. 39 (1): 89–93. doi:10.1042/BST0390089. PMID 21265752.

[4] Nakagawa, S; Niimura, Y; Gojobori, T (20. 4. 2017). "Comparative genomic analysis of translation initiation mechanisms for genes lacking the Shine-Dalgarno sequence in prokaryotes". Nucleic Acids Research. 45 (7): 3922–3931. doi:10.1093/nar/gkx124. PMC 5397173. PMID 28334743.

[5] Becker, T; Franckenberg, S; Wickles, S; Shoemaker, CJ; Anger, AM; Armache, JP; Sieber, H; Ungewickell, C; Berninghausen, O; Daberkow, I; Karcher, A; Thomm, M; Hopfner, KP; Green, R; Beckmann, R (22. 2. 2012). "Structural basis of highly conserved ribosome recycling in eukaryotes and archaea". Nature. 482 (7386): 501–6. Bibcode:2012Natur.482..501B. doi:10.1038/nature10829. PMC 6878762. PMID 22358840.

[6] French, S. L.; Santangelo, T. J.; Beyer, A. L.; Reeve, J. N. (30. 1. 2007). "Transcription and Translation are Coupled in Archaea". Molecular Biology and Evolution. 24 (4): 893–895. doi:10.1093/molbev/msm007. PMID 17237472.

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