NKRF

NKRF
Identifikatori
Aliasi	NKRF
Vanjski ID-jevi	OMIM: 300440 MGI: 1924536 HomoloGene: 84816 GeneCards: NKRF
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	119,606,443 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	36,167,166 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • vezivanje sa RNK; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • Jedarce; • nukleoplazma;
Biološki proces	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	55922
	77286
	ENSG00000186416
	ENSMUSG00000044149
	O15226
	Q8BY02
	NM_001173487; NM_001173488; NM_017544
	NM_029891
	NP_060014
	NP_084167
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NF-kapa-B-represirajući faktor je protein koji je kod ljudi kodiran genom NKRF.^[5]^[6]

Ovaj gen kodira faktor transkripcije koji stupa u interakciju sa određenim negativnim regulacijskim elementima (NRE) da posreduje u transkripcijskoj represiji određenih gena koji reagiraju na NK-kappa-B.

Protein se lokalizira pretežno na jedarcetu, malim udjelom koji se nalazi u nukleoplazmi i citoplazmi.^[6]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
^ ^a ^b "Entrez Gene: NKRF NF-kappaB repressing factor".

Dopunska literatura uredi

Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25". Gene. 192 (2): 291–8. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902.
Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. doi:10.1073/pnas.212306199. PMC 137863. PMID 12381793.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor". Mol. Cells. 16 (3): 397–401. PMID 14744032.
Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF". J. Cell Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMC 1190279. PMID 16107696.
Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550.
Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element". RNA. 13 (8): 1328–40. doi:10.1261/rna.545407. PMC 1924892. PMID 17592041.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10562553-5] Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.

[entrez-6] "Entrez Gene: NKRF NF-kappaB repressing factor".

[5]

[6]

[1]

[2]

[3]

[4]