THOC2

Podjedinica THO-kompleksa jest protein koji je kod ljudi kodiran genom THOC2.

THOC2
Identifikatori
Aliasi	THOC2
Vanjski ID-jevi	OMIM: 300395 MGI: 2442413 HomoloGene: 69669 GeneCards: THOC2
Lokacija gena (čovjek) Hrom. Hromosom X Bend Xq25 Početak 123,600,561 bp Kraj 123,733,056 bp
Lokacija gena (miš) Hrom. Hromosom X (miš) Bend X|X A4 Početak 40,883,868 bp Kraj 41,009,551 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK • mRNA binding Ćelijska komponenta • THO complex • nuclear speck • THO complex part of transcription export complex • transcription export complex • jedro • nukleoplazma Biološki proces • poly(A)+ mRNA export from nucleus • mRNA processing • mRNA transport • neuron development • viral mRNA export from host cell nucleus • Prerada RNK • generation of neurons • RNA export from nucleus • mRNA export from nucleus • mRNA 3'-end processing • GO:0000767 cell morphogenesis • blastocyst development • Regulacija ekspresije gena • regulation of mRNA export from nucleus • negative regulation of neuron projection development • stem cell division Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57187	331401
Ensembl	ENSG00000125676	ENSMUSG00000037475
UniProt	Q8NI27	B1AZI6
RefSeq (mRNK)	NM_001081550 NM_020449	NM_001033422
RefSeq (bjelančevina)	NP_001075019	NP_001028594
Lokacija (UCSC)	Chr X: 123.6 – 123.73 Mb	Chr X: 40.88 – 41.01 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

THO2 je dio kompleksa TREX (transkripcija /eksport), koji uključuje TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171) i UAP56 (MIM 606390) (prema OMIM-u).

Dopunska literatura

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• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Masuda S; Das R; Cheng H; et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
• Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA; Villén J; Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.