MORF4L2

MORF4L2
Identifikatori
Aliasi	MORF4L2
Vanjski ID-jevi	OMIM: 300409 MGI: 1927167 HomoloGene: 22710 GeneCards: MORF4L2
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	103,688,158 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	135,644,439 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• ćelijska membrana; • Jedarce; • jedro; • nukleoplazma; • NuA4 histone acetyltransferase complex; • histone acetyltransferase complex;
Biološki proces	• histone H2A acetylation; • chromatin remodeling; • regulation of growth; • GO:0009373 regulation of transcription, DNA-templated; • histone deacetylation; • GO:0100026 Popravka DNK; • transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of striated muscle cell differentiation; • cellular response to DNA damage stimulus; • histone H4 acetylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • histone acetylation;
	Izvori:Amigo / QuickGO
Ortolozi
	9643
	56397
	ENSG00000123562
	ENSMUSG00000031422
	Q15014
	Q9R0Q4
NM_012286; NM_001142418; NM_001142419; NM_001142420; NM_001142421;
	NM_001142422; NM_001142423; NM_001142424; NM_001142425; NM_001142426; NM_001142427; NM_001142428; NM_001142429; NM_001142430; NM_001142431; NM_001142432
NM_001168225; NM_001168226; NM_001168227; NM_001168228; NM_001168229;
	NM_001168230; NM_019768
NP_001135890; NP_001135891; NP_001135892; NP_001135893; NP_001135894;
	NP_001135895; NP_001135896; NP_001135897; NP_001135898; NP_001135899; NP_001135900; NP_001135901; NP_001135902; NP_001135903; NP_001135904; NP_036418
NP_001161697; NP_001161698; NP_001161699; NP_001161700; NP_001161701;
	NP_001161702; NP_062742
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 4-likog faktora mortaliteta 2 je protein koji je kod ljudi kodiran genom MORF4L2.^[5]^[6]^[7]

Funkcija uredi

Molekulska funkcija • GO: 0001948 vezanje na proteine

Ćelijska komponenta: • ćelijska membrana

• nukleolus • ćelijo jedro • nukleoplazma •kompleks NuA4 histon-acetiltransferaze • histon acetiltransferazni kompleks

Biološki proces • acetilacija histona H2A

• pregradnja hromatina • regulacija rasta • prigušivanje hromatina • regulacija transkripcije, sa predloškom DNK • deacetilacija histona • popravak DNK • transkripcija, sa DNK predloškom • pozitivna regulacija transkripcije iz promotora RNK polimeraze II • pozitivna regulacija prugaste diferencijacije mišićnih ćelija • ćelijski odgovor na stimulus oštećenja DNK • acetilacija histona H4 • organizacija hromatina • acetilacija histona

Izvori: Amigo / QuickGO

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123562 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031422 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.
^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
^ "Entrez Gene: MORF4L2 mortality factor 4 like 2".

Dopunska literatura uredi

Nomura N; Miyajima N; Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Sakai K; Shirakawa T; Li Y; et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID 11988016.
Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cai Y; Jin J; Tomomori-Sato C; et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Tominaga K; Leung JK; Rookard P; et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". J. Biol. Chem. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y; Jin J; Florens L; et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Ross MT; Grafham DV; Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Ewing RM; Chu P; Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123562 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031422 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9891081-5] Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.

[pmid7584026-6] Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.

[entrez-7] "Entrez Gene: MORF4L2 mortality factor 4 like 2".

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