Kortikotropinu slični intermedijarni peptid
Kortikotropinoliki intermedijarni peptid (CLIP), poznat i kao fragment adrenokortikotropnog hormona 18-39 [ACTH (18-39 )], je koji se prirodno pojavljuje kao endogeni neuropeptid sa dokosapeptidnom strukturom i sekvencom aminokiselina: Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod cijepanja veza u proteolizi fadenokortikotropnog hormona (ACTH),[1][2] što je zauzvrat produkt cijepanja proopiomelanokortina (POMC).[3] Njegova fiziološka uloga je istraživana u različitim tkivima,[4][5] posebno u centralnom nervnom sistemu.[6][7][8][9][10]
| Kortikotropinoliki intermedijarni peptid | |||||||
|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||
| Simbol | POMC | ||||||
| NCBI gen | 5443 | ||||||
| HGNC | 9201 | ||||||
| OMIM | 176830 | ||||||
| RefSeq | NM_000939 | ||||||
| UniProt | P01189 | ||||||
| Ostali podaci | |||||||
| Lokus | Hrom. 2 p23 | ||||||
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| Općenito | |
|---|---|
| Druga imena | IUPAC ime: L-arginil-L-prolil-L-valil-L-lizil-L-valil-L-tirozil-L-prolil-L-asparaginil-L-glicil-L-alanil-L-α-glutamil-L-α-aspartil-L-α-glutamil-L-seril-L-alanil-L-α-glutamil-L-alanil-L-fenilalanil-L-prolil-L-leucil-L-α-glutamil-L-fenilalanin |
| Molekularna formula | C112H165N27O36 |
| CAS registarski broj | 53917-42-3 |
| Osobine1 | |
| Molarna masa | 2465,668 g/mol |
| 1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima. | |
Reference
uredi- ^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (decembar 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883. Arhivirano s originala, 15. 9. 2019. Pristupljeno 27. 8. 2020.
- ^ Lloyd D. Fricker (24. 7. 1991). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25. 11. 2011.
- ^ Anthony W. Norman; Gerald Litwack (26. 9. 1997). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25. 11. 2011.
- ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (novembar 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
- ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (januar 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.
- ^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25. 11. 2011.
- ^ Chastrette N, Cespuglio R, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.
- ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.
- ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (mart 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.
- ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.
Vanjski linkovi
uredi- Corticotropin-Like Intermediate Lobe Peptide na US National Library of Medicine Medical Subject Headings (MeSH)
Commons ima datoteke na temu: Kortikotropinu slični intermedijarni peptid