RPA4

Podjedinica 30 kDa replikacijskog proteina je protein koji je kod ljudi kodiran genom RPA4.

RPA4
Identifikatori
Aliasi	RPA4
Vanjski ID-jevi	OMIM: 300767 HomoloGene: 88820 GeneCards: RPA4
Lokacija gena (čovjek) Hrom. Hromosom X Bend Xq21.33 Početak 96,883,908 bp Kraj 96,885,467 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • single-stranded DNA binding • vezivanje sa DNK • oštećeno vezivanje sa DNK • double-stranded DNA binding • GO:0001948, GO:0016582 vezivanje za proteine • sequence-specific DNA binding • G-rich strand telomeric DNA binding Ćelijska komponenta • Replikacijski protein A • jedro • nukleoplazma • Telomera • Hromatin • kondenzovani nuklearni hromosom • site of double-strand break Biološki proces • Popravak ekscizijom nukleotida • DNA damage checkpoint signaling • Replikacija DNK • DNA recombination • DNA replication initiation • nuclear DNA replication • GO:0100026 Popravka DNK • cellular response to DNA damage stimulus • G1/S transition of mitotic cell cycle • telomere maintenance via recombination • double-strand break repair via homologous recombination • DNA topological change • DNA unwinding involved in DNA replication • base-excision repair • Popravak neusklađenosti DNK • mitotic recombination • telomere maintenance via telomerase • reciprocal meiotic recombination • heteroduplex formation • positive regulation of helicase activity • regulation of DNA damage checkpoint Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	29935	n/a
Ensembl	ENSG00000204086	n/a
UniProt	Q13156	n/a
RefSeq (mRNK)	NM_013347	n/a
RefSeq (bjelančevina)	NP_037479	n/a
Lokacija (UCSC)	Chr X: 96.88 – 96.89 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Doppunska literatura

• Wu X, Yang Z, Liu Y, Zou Y (2006). "Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage". Biochem. J. 391 (Pt 3): 473–80. doi:10.1042/BJ20050379. PMC 1276948. PMID 15929725.
• Ross MT; Grafham DV; Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Parker A; Gu Y; Mahoney W; et al. (2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. 276 (8): 5547–55. doi:10.1074/jbc.M008463200. PMID 11092888.
• Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase". AIDS. 11 (4): 534–6. PMID 9084803.
• Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. doi:10.1128/mcb.15.10.5396. PMC 230789. PMID 7565690.