Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4H sa hromosoma 6.[5][6][7]

HIST1H4H
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Identifikatori
AliasiH4C8
Vanjski ID-jeviOMIM: 602828 MGI: 2448439 HomoloGene: 134461 GeneCards: H4C8
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za HIST1H4H
Genomska lokacija za HIST1H4H
Bend6p22.2Početak26,277,609 bp[1]
Kraj26,285,638 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za HIST1H4H
Genomska lokacija za HIST1H4H
Bend13|13 A3.1Početak21,934,364 bp[2]
Kraj21,934,675 bp[2]
Ontologija gena
Molekularna funkcija protein domain specific binding
GO:0001948, GO:0016582 protein binding
protein heterodimerization activity
DNA binding
GO:0031493 histone binding
RNA binding
Ćelijska komponenta membrana
hromosom
Nukleoplazma
extracellular region
nuclear chromosome
Nukleosom
Egzosom
Jedro
GO:0005578 Vanćelijski matriks
GO:0009327 protein-containing complex
Biološki proces telomere organization
epigenetic maintenance of chromatin in transcription-competent conformation
protein heterotetramerization
negative regulation of megakaryocyte differentiation
GO:0061641 CENP-A containing chromatin assembly
GO:0034723 DNA replication-dependent chromatin assembly
rDNA heterochromatin assembly
negative regulation of gene expression, epigenetic
DNA-templated transcription, initiation
double-strand break repair via nonhomologous end joining
beta-catenin-TCF complex assembly
telomere capping
nucleosome assembly
GO:1905616 regulation of gene silencing by miRNA
regulation of megakaryocyte differentiation
regulation of hematopoietic stem cell differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003543

NM_178211

RefSeq (bjelančevina)
NP_003537
NP_003486
NP_003535
NP_003539
NP_003531

NP_003536

NP_291074
NP_783587
NP_783588
NP_835499
NP_835500

NP_001182350
NP_835515
NP_783585
NP_783586
NP_835582
NP_835583
NP_783583
NP_694813

Lokacija (UCSC)Chr 6: 26.28 – 26.29 MbChr 13: 21.93 – 21.93 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Funkcija uredi

Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri jezgarna histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK-linkera između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen nalazi se u velikom klasteru histonskih gena na hromosomu 6.[7]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158406 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064288 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b "Entrez Gene: HIST1H4H histone cluster 1, H4h".

Dopunska literatura uredi