GMEB2

GMEB2
Identifikatori
Aliasi	GMEB2
Vanjski ID-jevi	OMIM: 607451 MGI: 2652836 HomoloGene: 8228 GeneCards: GMEB2
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	63,627,101 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	180,929,828 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • vezivanje sa DNK; • GO:0001105 transcription coactivator activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • nukleoplazma; • citoplazma; • citosol;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated; • positive regulation of nucleic acid-templated transcription;
	Izvori:Amigo / QuickGO
Ortolozi
	26205
	229004
	ENSG00000101216
	ENSMUSG00000038705
	Q9UKD1
	P58929
	NM_012384
	NM_198169
	NP_036516
	NP_937812
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Glukokortikoidni modulacijski element-vezujući protein 2 je protein koji je kod ljudi kodiran genom GMEB2.^[5]^[6]^[7]

Ovaj gen je član porodice gena KDWK. Njhegov proizvod povezuje se s proteinom GMEB1, a kompleks je neophodan za replikaciju DNK parvovirusa. Proučavanje homologa pacova implicira ulogu ovog gena u modulaciji transaktivacije glukokortikoidnim receptorom vezanim za elemente glukokortikoidnog odgovora. Čini se da ovaj gen koristi višestruka mjesta poliadenilacije.^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101216 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038705 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.
^ Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.
^ ^a ^b "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

Dopunska literatura uredi

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Kaul S, Blackford JA, Chen J, et al. (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–27. doi:10.1210/me.14.7.1010. PMID 10894151.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–9. doi:10.1074/jbc.M112330200. PMID 11812797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101216 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038705 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10523663-5] Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.

[pmid11743720-6] Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.

[entrez-7] "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

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