DBNDD2

DBNDD2
Identifikatori
Aliasi	DBNDD2
Vanjski ID-jevi	OMIM: 611453 MGI: 106562 HomoloGene: 12276 GeneCards: DBNDD2
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	45,410,610 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	164,335,239 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • synaptic vesicle membrane;
Biološki proces	• negative regulation of protein kinase activity; • neuron projection development;
	Izvori:Amigo / QuickGO
Ortolozi
	55861
	52840
	ENSG00000244274
	ENSMUSG00000017734
	Q9BQY9
	Q9CRD4
NM_018478; NM_001048221; NM_001048222; NM_001048223; NM_001048224;
	NM_001048225; NM_001048226; NM_001197139; NM_001197140
	NM_001048227; NM_001048228; NM_001048229; NM_026797
NP_001041686; NP_001041687; NP_001041688; NP_001041689; NP_001041690;
	NP_001041691; NP_001184068; NP_001184069; NP_060948
	NP_001041692; NP_001041693; NP_001041694; NP_081073
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Disbindinski domen-sadržavajući protein 2 je protein koji je kod ljudi kodiran genom DBNDD2.^[5]

Urađena je diferencijalna PCR analiza, kako bi se utvrdili geni izraženi u mijelomonocitnim matičnim ćelijama koštane srži (MSC) lišenih faktora matičnih ćelija (SCF). Podvrgnuti su brzoj apoptozi, ali ne u diferenciranju ili samoobnavljanju MSC-a, nakon čega slijedi RACE-PCR pacova i cDNK biblioteke ljudskog mozga, kloniranjem pacovskih i ljudskh DBNDD2; dobijeni su proteini zvani HSMNP1. Izvedeni ljudski protein sa 161 aminokiselinom dijeli 86% identiteta sekvence s Dbndd2 pacova, a oba proteina sadrže predviđeno mjesto N-glikozilacije, tri konsenzusna mjesta protein-kinaza C i kazein-kinaza II fosforilacije i C-krajev PEST region. Analiza genomske baze podataka pokazala je da je ekspresija ograničena na sisare. Imunohistokemijska analiza pokazala je citoplazmatsku, vezikulsku lokalizaciju tokom apoptotske indukcije.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244274 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017734 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2".
^ Lucas, T., Pratscher, B., Fink, D., Wolschek, M., Samorapoompichit, P., Schofer, C., Pehamberger, H., Muller, M., Sorensen, P., Jansen, B. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. Stem Cells Dev. 14: 556-563, 2005. [PubMed: 16305340]

Dopunska literatura

Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Lucas T, Pratscher B, Fink D, et al. (2006). "The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12". Stem Cells Dev. 14 (5): 556–63. doi:10.1089/scd.2005.14.556. PMID 16305340.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Yin H, Laguna KA, Li G, Kuret J (2006). "Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1". Biochemistry. 45 (16): 5297–308. doi:10.1021/bi052354e. PMID 16618118.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244274 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017734 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2".

[6] Lucas, T., Pratscher, B., Fink, D., Wolschek, M., Samorapoompichit, P., Schofer, C., Pehamberger, H., Muller, M., Sorensen, P., Jansen, B. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. Stem Cells Dev. 14: 556-563, 2005. [PubMed: 16305340]

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