Ciklaza

Ciklaze su enzimi, skoro uvijek lijaze, koje kataliziraju hemijsku reakciju da bi se formirao ciklični spoj. Važni ciklazni enzimi uključuju:^[1]^[2]^[3]^[4]

1. Adenilil-ciklaze, koje formiraju ciklični AMP iz adenozin-trifosfata (EC 4.6.1.1). To su:

2. Gvanilil-ciklaza, koja formira ciklički GMP iz gvanozin-trifosfata (EC 4.6.1.2)^[5]^[6]

3.Protein-ciklaza je ligaza enzim koji proizvodi proteine ciklirane oko kičme unutarmolekulskom transpeptidacijom.

Reference uredi

^ Hubberstey AV, Mottillo EP (april 2002). "Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization". FASEB Journal. 16 (6): 487–99. doi:10.1096/fj.01-0659rev. PMID 11919151. S2CID 24648371.
^ Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malhó R, Hussey PJ (august 2007). "Arabidopsis CAP1 - a key regulator of actin organisation and development". Journal of Cell Science. 120 (Pt 15): 2609–18. doi:10.1242/jcs.007302. PMID 17635992.
^ Freeman NL, Field J (februar 2000). "Mammalian homolog of the yeast cyclase associated protein, CAP/Srv2p, regulates actin filament assembly". Cell Motility and the Cytoskeleton. 45 (2): 106–20. doi:10.1002/(SICI)1097-0169(200002)45:2<106::AID-CM3>3.0.CO;2-3. PMID 10658207.
^ Hofmann A, Hess S, Noegel AA, Schleicher M, Wlodawer A (oktobar 2002). "Crystallization of cyclase-associated protein from Dictyostelium discoideum". Acta Crystallographica D. 58 (Pt 10 Pt 2): 1858–61. doi:10.1107/S0907444902013306. PMID 12351838.
^ Bertling E, Quintero-Monzon O, Mattila PK, Goode BL, Lappalainen P (april 2007). "Mechanism and biological role of profilin-Srv2/CAP interaction". Journal of Cell Science. 120 (Pt 7): 1225–34. doi:10.1242/jcs.000158. PMID 17376963.
^ Bertling E, Hotulainen P, Mattila PK, Matilainen T, Salminen M, Lappalainen P (maj 2004). "Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells". Molecular Biology of the Cell. 15 (5): 2324–34. doi:10.1091/mbc.E04-01-0048. PMC 404026. PMID 15004221.

Vanjski linkovi uredi

Portal Biologija

[pmid11919151-1] Hubberstey AV, Mottillo EP (april 2002). "Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization". FASEB Journal. 16 (6): 487–99. doi:10.1096/fj.01-0659rev. PMID 11919151. S2CID 24648371.

[pmid17635992-2] Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malhó R, Hussey PJ (august 2007). "Arabidopsis CAP1 - a key regulator of actin organisation and development". Journal of Cell Science. 120 (Pt 15): 2609–18. doi:10.1242/jcs.007302. PMID 17635992.

[pmid10658207-3] Freeman NL, Field J (februar 2000). "Mammalian homolog of the yeast cyclase associated protein, CAP/Srv2p, regulates actin filament assembly". Cell Motility and the Cytoskeleton. 45 (2): 106–20. doi:10.1002/(SICI)1097-0169(200002)45:2<106::AID-CM3>3.0.CO;2-3. PMID 10658207.

[pmid12351838-4] Hofmann A, Hess S, Noegel AA, Schleicher M, Wlodawer A (oktobar 2002). "Crystallization of cyclase-associated protein from Dictyostelium discoideum". Acta Crystallographica D. 58 (Pt 10 Pt 2): 1858–61. doi:10.1107/S0907444902013306. PMID 12351838.

[pmid17376963-5] Bertling E, Quintero-Monzon O, Mattila PK, Goode BL, Lappalainen P (april 2007). "Mechanism and biological role of profilin-Srv2/CAP interaction". Journal of Cell Science. 120 (Pt 7): 1225–34. doi:10.1242/jcs.000158. PMID 17376963.

[pmid15004221-6] Bertling E, Hotulainen P, Mattila PK, Matilainen T, Salminen M, Lappalainen P (maj 2004). "Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells". Molecular Biology of the Cell. 15 (5): 2324–34. doi:10.1091/mbc.E04-01-0048. PMC 404026. PMID 15004221.

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