CCT4

CCT4
Identifikatori
Aliasi	CCT4
Vanjski ID-jevi	OMIM: 605142 MGI: 104689 HomoloGene: 4695 GeneCards: CCT4
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	61,888,671 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	22,953,780 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • protein folding chaperone activity; • unfolded protein binding; • vezivanje sa RNK;
Ćelijska komponenta	• cell body; • centrosom; • projekcija ćelije; • Melanosom; • nukleoplazma; • centar organizacije mikrotubula; • zona pellucida receptor complex; • TRiC; • Mikrotubula; • Egzosom; • citoskelet; • citoplazma; • citosol;
Biološki proces	• positive regulation of protein localization to Cajal body; • positive regulation of establishment of protein localization to telomere; • scaRNA localization to Cajal body; • protein stabilization; • positive regulation of telomere maintenance via telomerase; • toxin transport; • Savijanje proteina; • positive regulation of telomerase activity; • positive regulation of telomerase RNA localization to Cajal body; • binding of sperm to zona pellucida; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	10575
	12464
	ENSG00000115484
	ENSMUSG00000007739
	P50991
	P80315
	NM_006430; NM_001256721
	NM_009837
	NP_001243650; NP_006421
	NP_033967
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica proteina 1 T-kompleksa delta je protein koji je kod ljudi kodiran iz gena CCT4.^[5]^[6] CCT4 protein je komponenta kompleksa TRiC

Interakcije

Pokazano je da CCT4 ulazi u interakcije sa PPP4C.^[7]^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115484 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007739 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
^ "Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta)".
^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Arhivirano s originala (PDF), 2. 3. 2021. Pristupljeno 1. 3. 2021.

Dopunska literatura

Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
Wu-Baer F, Lane WS, Gaynor RB (Feb 1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". The Journal of Biological Chemistry. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
Melki R, Batelier G, Soulié S, Williams RC (maj 1997). "Cytoplasmic chaperonin containing TCP-1: structural and functional characterization". Biochemistry. 36 (19): 5817–26. doi:10.1021/bi962830o. PMID 9153422.
Parissi V, Calmels C, De Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S (Dec 2001). "Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60". Journal of Virology. 75 (23): 11344–53. doi:10.1128/JVI.75.23.11344-11353.2001. PMC 114720. PMID 11689615.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi

Lokacija ljudskog genoma CCT4 i stranica sa detaljima o genu CCT4 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115484 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007739 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819444-5] Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.

[entrez-6] "Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta)".

[pmid18715871-7] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid16085932-8] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Arhivirano s originala (PDF), 2. 3. 2021. Pristupljeno 1. 3. 2021.

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