ARFIP2

ARFIP2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1I49, 1I4D, 1I4L, 1I4T, 4DCN
Identifikatori
Aliasi	ARFIP2
Vanjski ID-jevi	OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	6,481,479 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	105,289,623 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• phosphatidylinositol-4-phosphate binding; • protein domain specific binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GTP binding; • vezivanje identičnih proteina; • cadherin binding; • GTP-dependent protein binding; • phospholipid binding;
Ćelijska komponenta	• cell cortex; • trans-Golgi network membrane; • ćelijska membrana; • ruffle; • citosol; • citoplazma;
Biološki proces	• ruffle organization; • small GTPase mediated signal transduction; • actin cytoskeleton organization; • regulation of Arp2/3 complex-mediated actin nucleation; • lamellipodium assembly; • intracellular protein transport;
	Izvori:Amigo / QuickGO
Ortolozi
	23647
	76932
	ENSG00000132254
	ENSMUSG00000030881
	P53365
	Q8K221
	NM_001242854; NM_001242855; NM_001242856; NM_012402
	NM_029802
NP_001229783; NP_001229784; NP_001229785; NP_036534; NP_001357335;
	NP_001357337; NP_001357338; NP_001357340; NP_001357341; NP_001357342; NP_001363487; NP_001363488; NP_001363489; NP_001363490; NP_001363491; NP_001363492; NP_001363493
	NP_084078
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Arfaptin-2 je protein koji je kod ljudi kodiran genom ARFIP2.^[5]^[6]^[7]

Interakcije uredi

Pokazano je da ARFIP2 imainterakcije sa Arf6,^[8]^[9] ARF3,^[6] ARF5^[6]^[9] i RAC1.^[5]^[9]^[10]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Van Aelst L, Joneson T, Bar-Sagi D (august 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
^ ^a ^b ^c Kanoh H, Williger BT, Exton JH (februar 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
^ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (septembar 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
^ ^a ^b ^c Shin OH, Exton JH (august 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
^ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (maj 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.

Dopunska literatura uredi

D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (septembar 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (maj 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
Shin OH, Exton JH (august 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (mart 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
Lu L, Hong W (septembar 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (juni 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (oktobar 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8670882-5] Van Aelst L, Joneson T, Bar-Sagi D (august 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.

[pmid9038142-6] Kanoh H, Williger BT, Exton JH (februar 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.

[entrez-7] "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".

[pmid9312003-8] D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (septembar 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.

[pmid11478794-9] Shin OH, Exton JH (august 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.

[pmid11346801-10] Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (maj 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

[9]

[10]