APOO

APOO
Identifikatori
Aliasi	APOO
Vanjski ID-jevi	OMIM: 300753 MGI: 1915566 HomoloGene: 11475 GeneCards: APOO
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	23,907,938 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	93,460,699 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• high-density lipoprotein particle; • extracellular region; • mitochondrial inner membrane; • endoplasmic reticulum membrane; • very-low-density lipoprotein particle; • Golđijeva membrana; • Golđijev aparat; • membrana; • integral component of membrane; • integral component of mitochondrial inner membrane; • mitohondrija; • Endoplazmatski retikulum; • low-density lipoprotein particle; • MICOS complex; • Vanćelijsko; • citosol;
Biološki proces	• lipid transport; • cristae formation; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	79135
	68316
	ENSG00000184831
	ENSMUSG00000079508
	Q9BUR5
	Q9DCZ4
	NM_024122
	NM_001199337; NM_001199338; NM_001199339; NM_026673
	NP_077027
	NP_001186266; NP_001186267; NP_001186268; NP_080949
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Apolipoprotein O, znan i kao protein FAM121B je protein koji je kod ljudi kodiran genom APOO. APOO je član porodice apolipoproteina.^[5]

Ljudski apolipoprotein O je 198-aminokiselinski protein, koji sadrži 23 aminokiseline dug0g signalnog peptida. Apoprotein se izlučuje pomoću mikrosomskog trigliceridnog mehanizma, ovisnog o proteinu (MTTP), vjerovatno kao VLDL-vezani protein, koji se potom prenosi u HDL. Apolipoprotein O je prvi hondroitin-sulfatni lanac koji sadrži apolipoprotein.^[5]

Apolipoproteini se vežu za lipide. Članovi ove porodice promoviraju otpuštabje holesterola iz ćelijskih makrofaga. Prisutni su u različitim lipoproteinskim kompleksima, uključujući HDL, LDL i VLDL.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184831 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079508 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (novembar 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892.

Vanjski linkovi

Lokacija ljudskog genoma APOO i stranica sa detaljima o genu APOO u UCSC Genome Browseru.

Dopunska literatura

Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184831 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079508 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16956892-5] Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (novembar 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892.

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