TSPYL5

5-oliki protein TSPY jest protein koji je kod ljudi kodiran genom TSPYL5.

TSPYL5
Identifikatori
Aliasi	TSPYL5
Vanjski ID-jevi	OMIM: 614721 MGI: 2442458 HomoloGene: 14134 GeneCards: TSPYL5
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8q22.1 Početak 97,273,488 bp Kraj 97,277,928 bp
Lokacija gena (miš) Hrom. Hromosom 15 (miš) Bend 15|15 B3.1 Početak 33,684,021 bp Kraj 33,688,030 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • jedro Biološki proces • regulation of growth • nucleosome assembly • positive regulation of protein kinase B signaling • positive regulation of protein ubiquitination • cellular response to gamma radiation • positive regulation of cell population proliferation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	85453	239364
Ensembl	ENSG00000180543	ENSMUSG00000038984
UniProt	Q86VY4	Q69ZB3
RefSeq (mRNK)	NM_033512	NM_001085421
RefSeq (bjelančevina)	NP_277047	NP_001078890
Lokacija (UCSC)	Chr 8: 97.27 – 97.28 Mb	Chr 15: 33.68 – 33.69 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dopunska literatura

• Jung Y, Park J, Bang YJ, Kim TY (februar 2008). "Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers". Lab. Invest. 88 (2): 153–60. doi:10.1038/labinvest.3700706. PMID 18059362.
• Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG (februar 2010). "TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway". Biochem. Biophys. Res. Commun. 392 (3): 448–53. doi:10.1016/j.bbrc.2010.01.045. PMID 20079711.
• Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R (januar 2011). "TSPYL5 suppresses p53 levels and function by physical interaction with USP7". Nat. Cell Biol. 13 (1): 102–8. doi:10.1038/ncb2142. PMID 21170034.
• Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM (april 2013). "TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression". Mol. Endocrinol. 27 (4): 657–70. doi:10.1210/me.2012-1397. PMC 3607698. PMID 23518928.
• Qiu X, Hu B, Huang Y, Deng Y, Wang X, Zheng F (januar 2016). "Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance". Dig. Dis. Sci. 61 (1): 149–57. doi:10.1007/s10620-015-3878-3. PMID 26386860.
• Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V (maj 2016). "Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression". Hum. Mol. Genet. 25 (9): 1714–27. doi:10.1093/hmg/ddw043. PMC 4986328. PMID 26911678.
• Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, Ponnusamy MP, Batra SK, Ganti AK (juli 2017). "MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53". Clin. Cancer Res. 23 (14): 3906–3917. doi:10.1158/1078-0432.CCR-16-2530. PMC 5511558. PMID 28196872.
• Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ (februar 2017). "Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma". BMC Cancer. 17 (1): 158. doi:10.1186/s12885-017-3134-7. PMC 5326500. PMID 28235398.
• Shao L, Shen Z, Qian H, Zhou S, Chen Y (decembar 2017). "Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5". DNA Cell Biol. 36 (12): 1108–1116. doi:10.1089/dna.2017.3904. PMID 28972400.