Polipeptid alfa glikoproteinskog hormona
Polipeptidni alfa glikproteinski hormon je protein kojeg kodira gen CGA.[1]
Polipeptid alfa glikoproteinskog hormona | |||||||
|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||
| Simbol | CGA | ||||||
| NCBI gen | 1081 | ||||||
| HGNC | 1885 | ||||||
| OMIM | 118850 | ||||||
| PDB | 1DZ7 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XUL, 1XWD | ||||||
| RefSeq | NM_000735 | ||||||
| UniProt | P01215 | ||||||
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Gonadotropinski hormoni: horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulirajući hormon (FSH) i tireostimulirajući hormon (TSH) su heterodimeri koji se sastoje od alfa i beta podjedinica (koje se nazivaju i lanci), a koje su povezane nekovalentno.
Alfa podjedinice ova četiri ljudska glikoproteinska hormona su identične; međutim njihovi beta lanci jedinstveni su i daju biološku specifičnost. Protein kodiran ovim genom je alfa podjedinica i pripada porodici alfa lanaca glikoprotenskih hormona.[2]
Reference
uredi- ^ Fiddes JC, Goodman HM (Oct 1982). "The gene encoding the common alpha subunit of the four human glycoprotein hormones". Journal of Molecular and Applied Genetics. 1 (1): 3–18. PMID 6286817. Referenca sadrži prazan nepoznati parametar:
|1=(pomoć) - ^ "Entrez Gene: CGA glycoprotein hormones, alpha polypeptide".
Dopunska literatura
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- Sairam MR, Li CH (Jul 1977). "Human pituitary thyrotropin. The primary structure of the alpha and beta subunits". Canadian Journal of Biochemistry. 55 (7): 755–60. doi:10.1139/o77-108. PMID 890569.
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- Harris DC, Machin KJ, Evin GM, Morgan FJ, Isaacs NW (Apr 1989). "Preliminary X-ray diffraction analysis of human chorionic gonadotropin". The Journal of Biological Chemistry. 264 (12): 6705–6. PMID 2708337.
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