Folitropinska podjedinica beta
Folitropinska podjedinica beta ili beta podjedinica folitropina, poznata i kao beta podjedinica folikulostimulirajućeg hormona (FSH-B) je protein kojeg kod ljudi kodira gen FSHB.[1][2][3] Alternativna prerada iRNK rezultira u dvije varijante transkripta koje kodiraju isti protein.
| Folitropinska podjedinica beta (FSHB)  | |||||||
|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||
| Simbol | FSHB | ||||||
| NCBI gen | 2488 | ||||||
| HGNC | 3964 | ||||||
| OMIM | 136530 | ||||||
| PDB | 1FL7 1XWD | ||||||
| RefSeq | NM_000510.2 | ||||||
| UniProt | P01225 | ||||||
| |||||||
Funkcija
urediPorodica hipofiznog glikoproteina uključuje folikulostimulirajući hormon, luteinizirajući hormon, horionski gonadotropin i tiroid- stimulirajući homon. Svi ovi glikoproteini sastoje se od identične alfa i beta podjedinice specifične za hormon. Ovaj gen kodira beta podjedinicu folikulostimulirajućeg hormona. U kombinaciji s luteinizirajućim hormonom, folikulostimulirajući hormon podstiče stvaranje jajnih ćelija i sperme.[3]
Reference
uredi- ^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA. 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163.
- ^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J Protein Chem. 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250.
- ^ a b "Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide".
Dopunska literatura
uredi- Barrios-De-Tomasi J; Timossi C; Merchant H; et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones". Mol. Cell. Endocrinol. 186 (2): 189–98. doi:10.1016/S0303-7207(01)00657-8. PMID 11900895. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Saxena BB, Rathnam P (1976). "Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands". J. Biol. Chem. 251 (4): 993–1005. PMID 1249074.
- Keene JL; Matzuk MM; Otani T; et al. (1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells". J. Biol. Chem. 264 (9): 4769–75. PMID 2494176. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids". Mol. Endocrinol. 2 (9): 806–15. doi:10.1210/mend-2-9-806. PMID 3139991.
- Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)". J. Clin. Endocrinol. Metab. 39 (1): 203–5. doi:10.1210/jcem-39-1-203. PMID 4835136.
- Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone". Biochim. Biophys. Acta. 624 (2): 428–35. doi:10.1016/0005-2795(80)90084-7. PMID 6774759.
- Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men". Cell Tissue Res. 278 (3): 595–600. doi:10.1007/BF00331379. PMID 7850869.
- Matthews CH; Borgato S; Beck-Peccoz P; et al. (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone". Nat. Genet. 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Layman LC; Lee EJ; Peak DB; et al. (1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene". N. Engl. J. Med. 337 (9): 607–11. doi:10.1056/NEJM199708283370905. PMID 9271483. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Cargill M; Altshuler D; Ireland J; et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1–3): 67–71. doi:10.1016/S0167-0115(99)00022-1. PMID 10395410.
- Ben-Menahem D; Hyde R; Pixley M; et al. (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry. 38 (46): 15070–7. doi:10.1021/bi991510c. PMID 10563789. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Fox KM, Dias JA, Van Roey P (2001). "Three-dimensional structure of human follicle-stimulating hormone". Mol. Endocrinol. 15 (3): 378–89. doi:10.1210/me.15.3.378. PMID 11222739.
- Amoresano A; Orrù S; Siciliano RA; et al. (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain". Biol. Chem. 382 (6): 961–8. doi:10.1515/BC.2001.120. PMID 11501762. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć) - Walton WJ; Nguyen VT; Butnev VY; et al. (2001). "Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. Clin. Endocrinol. Metab. 86 (8): 3675–85. doi:10.1210/jc.86.8.3675. PMID 11502795. Nepoznati parametar
|name-list-format=zanemaren (prijedlog zamjene:|name-list-style=) (pomoć)