Mali protein
Mali proteini su raznolika klasa proteinskih nabora (obično dužine <100 aminokiselina).[1][2][3] Njihovu trodimenzijsku strukturu obično održavaju disulfidni mostovi,[4] metalni ligandi,[5] i/ili kofaktori kao što je hem. Neki mali proteini služe važnim regulatornim funkcijama direktnom interakcijom s određenim enzimima i stoga su također zanimljiv alat za biotehnološke primjene u mikroorganizmima.[6]
Također pogledajte uredi
Reference uredi
- ^ Kihara D, Skolnick J (decembar 2003). "The PDB is a covering set of small protein structures". Journal of Molecular Biology. 334 (4): 793–802. doi:10.1016/j.jmb.2003.10.027. PMID 14636603.
- ^ Su M, Ling Y, Yu J, Wu J, Xiao J (decembar 2013). "Small proteins: untapped area of potential biological importance". Frontiers in Genetics. 4: 286. doi:10.3389/fgene.2013.00286. PMC 3864261. PMID 24379829.
- ^ Storz G, Wolf YI, Ramamurthi KS (2. 6. 2014). "Small proteins can no longer be ignored". Annual Review of Biochemistry. 83 (1): 753–77. doi:10.1146/annurev-biochem-070611-102400. PMC 4166647. PMID 24606146.
- ^ Cheek S, Krishna SS, Grishin NV (maj 2006). "Structural classification of small, disulfide-rich protein domains". Journal of Molecular Biology. 359 (1): 215–37. doi:10.1016/j.jmb.2006.03.017. PMID 16618491.
- ^ Berg JM (april 1990). "Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules". The Journal of Biological Chemistry. 265 (12): 6513–6. PMID 2108957.
- ^ Brandenburg F, Klähn S (2020). "Small but smart: On the diverse role of small proteins in the regulation of cyanobacterial metabolism". Life. 10 (12): 1–15. doi:10.3390/life10120322. PMC 7760959.