USP6
Ubikvitin karboksil-terminalna hidrolaza 6 je enzim koji je kod ljudi kodiran genom USP6.[3][4][5]
Aneurizamska cista kostiju može se povezati sa translokacijom TRE17/USP6 na hromosomu 17.[6]
Dužina polipeptidnog lanca je 1.406 aminokiselina, a molekulska težina 158.658 Da.[7].
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDMVENADSL | QAQERKDILM | KYDKGHRAGL | PEDKGPEPVG | INSSIDRFGI | ||||
| LHETELPPVT | AREAKKIRRE | MTRTSKWMEM | LGEWETYKHS | SKLIDRVYKG | ||||
| IPMNIRGPVW | SVLLNIQEIK | LKNPGRYQIM | KERGKRSSEH | IHHIDLDVRT | ||||
| TLRNHVFFRD | RYGAKQRELF | YILLAYSEYN | PEVGYCRDLS | HITALFLLYL | ||||
| PEEDAFWALV | QLLASERHSL | PGFHSPNGGT | VQGLQDQQEH | VVPKSQPKTM | ||||
| WHQDKEGLCG | QCASLGCLLR | NLIDGISLGL | TLRLWDVYLV | EGEQVLMPIT | ||||
| SIALKVQQKR | LMKTSRCGLW | ARLRNQFFDT | WAMNDDTVLK | HLRASTKKLT | ||||
| RKQGDLPPPA | KREQGSLAPR | PVPASRGGKT | LCKGYRQAPP | GPPAQFQRPI | ||||
| CSASPPWASR | FSTPCPGGAV | REDTYPVGTQ | GVPSLALAQG | GPQGSWRFLE | ||||
| WKSMPRLPTD | LDIGGPWFPH | YDFEWSCWVR | AISQEDQLAT | CWQAEHCGEV | ||||
| HNKDMSWPEE | MSFTANSSKI | DRQKVPTEKG | ATGLSNLGNT | CFMNSSIQCV | ||||
| SNTQPLTQYF | ISGRHLYELN | RTNPIGMKGH | MAKCYGDLVQ | ELWSGTQKSV | ||||
| APLKLRRTIA | KYAPKFDGFQ | QQDSQELLAF | LLDGLHEDLN | RVHEKPYVEL | ||||
| KDSDGRPDWE | VAAEAWDNHL | RRNRSIIVDL | FHGQLRSQVK | CKTCGHISVR | ||||
| FDPFNFLSLP | LPMDSYMDLE | ITVIKLDGTT | PVRYGLRLNM | DEKYTGLKKQ | ||||
| LRDLCGLNSE | QILLAEVHDS | NIKNFPQDNQ | KVQLSVSGFL | CAFEIPVPSS | ||||
| PISASSPTQI | DFSSSPSTNG | MFTLTTNGDL | PKPIFIPNGM | PNTVVPCGTE | ||||
| KNFTNGMVNG | HMPSLPDSPF | TGYIIAVHRK | MMRTELYFLS | PQENRPSLFG | ||||
| MPLIVPCTVH | TRKKDLYDAV | WIQVSWLARP | LPPQEASIHA | QDRDNCMGYQ | ||||
| YPFTLRVVQK | DGNSCAWCPQ | YRFCRGCKID | CGEDRAFIGN | AYIAVDWHPT | ||||
| ALHLRYQTSQ | ERVVDKHESV | EQSRRAQAEP | INLDSCLRAF | TSEEELGESE | ||||
| MYYCSKCKTH | CLATKKLDLW | RLPPFLIIHL | KRFQFVNDQW | IKSQKIVRFL | ||||
| RESFDPSAFL | VPRDPALCQH | KPLTPQGDEL | SKPRILAREV | KKVDAQSSAG | ||||
| KEDMLLSKSP | SSLSANISSS | PKGSPSSSRK | SGTSCPSSKN | SSPNSSPRTL | ||||
| GRSKGRLRLP | QIGSKNKPSS | SKKNLDASKE | NGAGQICELA | DALSRGHMRG | ||||
| GSQPELVTPQ | DHEVALANGF | LYEHEACGNG | CGDGYSNGQL | GNHSEEDSTD | ||||
| DQREDTHIKP | IYNLYAISCH | SGILSGGHYI | TYAKNPNCKW | YCYNDSSCEE | ||||
| LHPDEIDTDS | AYILFYEQQG | IDYAQFLPKI | DGKKMADTSS | TDEDSESDYE | ||||
| KYSMLQ |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000129204 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
- ^ Hoogendijk JE, Hensels GW, Gabreels-Festen AA, Gabreels FJ, Janssen EA, de Jonghe P, Martin JJ, van Broeckhoven C, Valentijn LJ, Baas F, et al. (maj 1992). "De-novo mutation in hereditary motor and sensory neuropathy type I". Lancet. 339 (8801): 1081–2. doi:10.1016/0140-6736(92)90668-S. PMID 1349106. S2CID 35908066.
- ^ "Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene)".
- ^ Ye Y, Pringle LM, Lau AW, et al. (juni 2010). "TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NFκB". Oncogene. 29 (25): 3619–29. doi:10.1038/onc.2010.116. PMC 2892027. PMID 20418905.
- ^ "UniProt, P35125". Pristupljeno , June 17, 2021. Provjerite vrijednost datuma u parametru:
|access-date=(pomoć)
Dopunska literatura uredi
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- Nakamura T, Hillova J, Mariage-Samson R, et al. (1992). "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells". Oncogene. 7 (4): 733–41. PMID 1565468.
- Papa FR, Hochstrasser M (1993). "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene". Nature. 366 (6453): 313–9. doi:10.1038/366313a0. PMID 8247125. S2CID 4273807.
- Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID 8406013.
- Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID 8471161.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMC 151371. PMID 12604796.
- Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC 149457. PMID 12612085.
- Bizimungu C, De Neve N, Burny A, et al. (2003). "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene". Biochem. Biophys. Res. Commun. 310 (2): 498–504. doi:10.1016/j.bbrc.2003.09.051. PMID 14521938.
- Oliveira AM, Hsi BL, Weremowicz S, et al. (2004). "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst". Cancer Res. 64 (6): 1920–3. doi:10.1158/0008-5472.CAN-03-2827. PMID 15026324.
- Oliveira AM, Perez-Atayde AR, Inwards CY, et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. doi:10.1016/S0002-9440(10)63432-3. PMC 3278819. PMID 15509545.
- Martinu L, Masuda-Robens JM, Robertson SE, et al. (2004). "The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004. PMC 525471. PMID 15509780.
- Oliveira AM, Perez-Atayde AR, Dal Cin P, et al. (2005). "Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes". Oncogene. 24 (21): 3419–26. doi:10.1038/sj.onc.1208506. PMID 15735689.
- Bizimungu C, Vandenbol M (2005). "At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity". Biochem. Biophys. Res. Commun. 335 (3): 883–90. doi:10.1016/j.bbrc.2005.07.159. PMID 16099424.
- Shen C, Ye Y, Robertson SE, et al. (2006). "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6". J. Biol. Chem. 280 (43): 35967–73. doi:10.1074/jbc.M505220200. PMID 16127172.
- Dechamps C, Bach S, Portetelle D, Vandenbol M (2006). "The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton". Biotechnol. Lett. 28 (4): 223–31. doi:10.1007/s10529-005-5523-2. PMID 16555005. S2CID 25625056.