UBXN6
UBX domenski protein 6 je protein koji je kod ljudi kodiran genom UBXN6.[5]
Dužina proteinskog polipeptidnog lanca je 441 aminokiselina, molekulske težine 49,754.
Protein koji je kodiran oim genom, po funkciji pripada fosfoproteinima. Alternativna prerada uključena je u takve biološke procese kao što je ubikvitinacija proteina. Lokaliziran je u citoplazmi, citoskeletu, jedru, membrani, lizosomima i endosomima.
Aminokiselinska sekvenca uredi
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKKFFQEFKA | DIKFKSAGPG | QKLKESVGEK | AHKEKPNQPA | PRPPRQGPTN | ||||
| EAQMAAAAAL | ARLEQKQSRA | WGPTSQDTIR | NQVRKELQAE | ATVSGSPEAP | ||||
| GTNVVSEPRE | EGSAHLAVPG | VYFTCPLTGA | TLRKDQRDAC | IKEAILLHFS | ||||
| TDPVAASIMK | IYTFNKDQDR | VKLGVDTIAK | YLDNIHLHPE | EEKYRKIKLQ | ||||
| NKVFQERINC | LEGTHEFFEA | IGFQKVLLPA | QDQEDPEEFY | VLSETTLAQP | ||||
| QSLERHKEQL | LAAEPVRAKL | DRQRRVFQPS | PLASQFELPG | DFFNLTAEEI | ||||
| KREQRLRSEA | VERLSVLRTK | AMREKEEQRG | LRKYNYTLLR | VRLPDGCLLQ | ||||
| GTFYARERLG | AVYGFVREAL | QSDWLPFELL | ASGGQKLSED | ENLALNECGL | ||||
| VPSALLTFSW | DMAVLEDIKA | AGAEPDSILK | PELLSAIEKL | L |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167671 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019578 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: UBX domain protein 6".
Dopunska literatura uredi
- Stapf C, Cartwright E, Bycroft M, Hofmann K, Buchberger A (novembar 2011). "The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors". The Journal of Biological Chemistry. 286 (44): 38670–8. doi:10.1074/jbc.M111.274472. PMC 3207395. PMID 21896481.
- Nagahama M, Ohnishi M, Kawate Y, Matsui T, Miyake H, Yuasa K, Tani K, Tagaya M, Tsuji A (maj 2009). "UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation". Biochemical and Biophysical Research Communications. 382 (2): 303–8. doi:10.1016/j.bbrc.2009.03.012. PMID 19275885.
- Falsone SF, Gesslbauer B, Rek A, Kungl AJ (juli 2007). "A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome". Proteomics. 7 (14): 2375–83. doi:10.1002/pmic.200600996. PMID 17623298.
- Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H (august 2011). "Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations". Nature Cell Biology. 13 (9): 1116–23. doi:10.1038/ncb2301. PMC 3246400. PMID 21822278.
- Madsen L, Andersen KM, Prag S, Moos T, Semple CA, Seeger M, Hartmann-Petersen R (2008). "Ubxd1 is a novel co-factor of the human p97 ATPase". The International Journal of Biochemistry & Cell Biology. 40 (12): 2927–42. doi:10.1016/j.biocel.2008.06.008. PMID 18656546.
- Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ (septembar 2008). "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover". Cell. 134 (5): 804–16. doi:10.1016/j.cell.2008.06.048. PMC 2614663. PMID 18775313.
- Kern M, Fernandez-Sáiz V, Schäfer Z, Buchberger A (mart 2009). "UBXD1 binds p97 through two independent binding sites". Biochemical and Biophysical Research Communications. 380 (2): 303–7. doi:10.1016/j.bbrc.2009.01.076. PMID 19174149.
- Carim-Todd L, Escarceller M, Estivill X, Sumoy L (januar 2001). "Identification and characterization of UBXD1, a novel UBX domain-containing gene on human chromosome 19p13, and its mouse ortholog". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1517 (2): 298–301. doi:10.1016/s0167-4781(00)00248-7. PMID 11342112.