Sintaksin-12 jest protein koji je kod ljudi kodiran genom STX12 sa hromosoma 1.[5][6]

STX12
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2DNX

Identifikatori
AliasiSTX12
Vanjski ID-jeviOMIM: 606892 MGI: 1931027 HomoloGene: 128192 GeneCards: STX12
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za STX12
Genomska lokacija za STX12
Bend1p35.3Početak27,773,219 bp[1]
Kraj27,824,443 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za STX12
Genomska lokacija za STX12
Bend4 D2.3|4 66.01 cMPočetak132,580,812 bp[2]
Kraj132,611,820 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija SNAP receptor activity
GO:0001948, GO:0016582 vezivanje za proteine
SNARE binding
Ćelijska komponenta integral component of membrane
Vezikula
endozom
Golđijev aparat
membrana
Golđijeva membrana
BLOC-1 complex
phagophore assembly site
SNARE complex
phagocytic vesicle
Lipidni splav
endosome membrane
Endomembranski sistem
early endosome membrane
recycling endosome membrane
Sinapsna vezikula
integral component of synaptic vesicle membrane
postsynaptic recycling endosome
Biološki proces protein stabilization
autophagosome assembly
vesicle docking
cholesterol efflux
protein transport
intracellular protein transport
Fuzija vezikula
vesicle-mediated transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_177424

NM_133887

RefSeq (bjelančevina)

NP_803173

NP_598648

Lokacija (UCSC)Chr 1: 27.77 – 27.82 MbChr 4: 132.58 – 132.61 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 276 aminokiselina, a molekulska težina 31.642 Da.[6]

1020304050
MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQL
GTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQR
LQKERLMNDFSAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREE
QLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQ
IFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYYQKKSRKK
MCILVLVLSVIILILGLIIWLVYKTK

Interakcije

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Pokazalo se da STX12 ima interakcije sa PLDN.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117758 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028879 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.
  6. ^ a b "Entrez Gene: STX12 syntaxin 12".
  7. ^ Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180. S2CID 22843205.

Dopunska literatura

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Vanjski linkovi

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-12