STX12

STX12
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DNX
Identifikatori
Aliasi	STX12
Vanjski ID-jevi	OMIM: 606892 MGI: 1931027 HomoloGene: 128192 GeneCards: STX12
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	27,824,443 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	132,611,820 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• SNAP receptor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • SNARE binding;
Ćelijska komponenta	• integral component of membrane; • Vezikula; • endozom; • Golđijev aparat; • membrana; • Golđijeva membrana; • BLOC-1 complex; • phagophore assembly site; • SNARE complex; • phagocytic vesicle; • Lipidni splav; • endosome membrane; • Endomembranski sistem; • early endosome membrane; • recycling endosome membrane; • Sinapsna vezikula; • integral component of synaptic vesicle membrane; • postsynaptic recycling endosome;
Biološki proces	• protein stabilization; • autophagosome assembly; • vesicle docking; • cholesterol efflux; • protein transport; • intracellular protein transport; • Fuzija vezikula; • vesicle-mediated transport;
	Izvori:Amigo / QuickGO
Ortolozi
	23673
	100226
	ENSG00000117758
	ENSMUSG00000028879
	Q86Y82
	Q9ER00
	NM_177424
	NM_133887
	NP_803173
	NP_598648
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintaksin-12 jest protein koji je kod ljudi kodiran genom STX12 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 276 aminokiselina, a molekulska težina 31.642 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSYGPLDMYR	NPGPSGPQLR	DFSSIIQTCS	GNIQRISQAT	AQIKNLMSQL
GTKQDSSKLQ	ENLQQLQHST	NQLAKETNEL	LKELGSLPLP	LSTSEQRQQR
LQKERLMNDF	SAALNNFQAV	QRRVSEKEKE	SIARARAGSR	LSAEERQREE
QLVSFDSHEE	WNQMQSQEDE	VAITEQDLEL	IKERETAIRQ	LEADILDVNQ
IFKDLAMMIH	DQGDLIDSIE	ANVESSEVHV	ERATEQLQRA	AYYQKKSRKK
MCILVLVLSV	IILILGLIIW	LVYKTK

Interakcije uredi

Pokazalo se da STX12 ima interakcije sa PLDN.^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117758 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028879 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.
^ ^a ^b "Entrez Gene: STX12 syntaxin 12".
^ Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180. S2CID 22843205.

Dopunska literatura uredi

Falcón-Pérez JM, Dell'Angelica EC (April 2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis". Pigment Cell Research. 15 (2): 82–6. doi:10.1034/j.1600-0749.2002.1r082.x. PMID 11936273.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (April 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
Prekeris R, Klumperman J, Chen YA, Scheller RH (November 1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes". The Journal of Cell Biology. 143 (4): 957–71. doi:10.1083/jcb.143.4.957. PMC 2132958. PMID 9817754.
Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M (August 1999). "Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13". Cell. 98 (3): 377–86. doi:10.1016/S0092-8674(00)81966-2. PMID 10458612. S2CID 2516425.
Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180. S2CID 22843205.
Minakami R, Kato A, Sugiyama H (June 2000). "Interaction of Vesl-1L/Homer 1c with syntaxin 13". Biochemical and Biophysical Research Communications. 272 (2): 466–71. doi:10.1006/bbrc.2000.2777. PMID 10833436.
Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S (June 2000). "Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking". The European Journal of Neuroscience. 12 (6): 1913–23. doi:10.1046/j.1460-9568.2000.00076.x. PMID 10886332. S2CID 19547759.
Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, Hirling H (June 2002). "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD". The Journal of Cell Biology. 157 (7): 1197–209. doi:10.1083/jcb.200202022. PMC 2173541. PMID 12070131.
Sun W, Yan Q, Vida TA, Bean AJ (July 2003). "Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex". The Journal of Cell Biology. 162 (1): 125–37. doi:10.1083/jcb.200302083. PMC 2172712. PMID 12847087.
Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G (December 2004). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Molecular Biology of the Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi uredi

PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-12

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117758 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028879 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9507000-5] Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.

[entrez-6] "Entrez Gene: STX12 syntaxin 12".

[pmid10610180-7] Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180. S2CID 22843205.

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