SARDH

SARDH
Identifikatori
Aliasi	SARDH
Vanjski ID-jevi	OMIM: 604455 MGI: 2183102 HomoloGene: 5149 GeneCards: SARDH
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	133,739,955 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	27,138,349 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • sarcosine dehydrogenase activity;
Ćelijska komponenta	• mitohondrija; • mitochondrial matrix; • citoplazma;
Biološki proces	• choline catabolic process; • sarcosine catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	1757
	192166
	ENSG00000123453
	ENSMUSG00000009614
	Q9UL12
	Q99LB7
	NM_001134707; NM_007101
	NM_138665
	NP_001128179; NP_009032
	NP_619606
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijska sarkozin-dehidrogenaza je enzim koji je kod ljudi kodiran genom SARDH.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 918 aminokiselina, а molekulska težina 101.037 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASLSRALRV	AAAHPRQSPT	RGMGPCNLSS	AAGPTAEKSV	PYQRTLKEGQ
GTSVVAQGPS	RPLPSTANVV	VIGGGSLGCQ	TLYHLAKLGM	SGAVLLERER
LTSGTTWHTA	GLLWQLRPSD	VEVELLAHTR	RVVSRELEEE	TGLHTGWIQN
GGLFIASNRQ	RLDEYKRLMS	LGKAYGVESH	VLSPAETKTL	YPLMNVDDLY
GTLYVPHDGT	MDPAGTCTTL	ARAASARGAQ	VIENCPVTGI	RVWTDDFGVR
RVAGVETQHG	SIQTPCVVNC	AGVWASAVGR	MAGVKVPLVA	MHHAYVVTER
IEGIQNMPNV	RDHDASVYLR	LQGDALSVGG	YEANPIFWEE	VSDKFAFGLF
DLDWEVFTQH	IEGAINRVPV	LEKTGIKSTV	CGPESFTPDH	KPLMGEAPEL
RGFFLGCGFN	SAGMMLGGGC	GQELAHWIIH	GRPEKDMHGY	DIRRFHHSLT
DHPRWIRERS	HESYAKNYSV	VFPHDEPLAG	RNMRRDPLHE	ELLGQGCVFQ
ERHGWERPGW	FHPRGPAPVL	EYDYYGAYGS	RAHEDYAYRR	LLADEYTFAF
PPHHDTIKKE	CLACRGAAAV	FDMSYFGKFY	LVGLDARKAA	DWLFSADVSR
PPGSTVYTCM	LNHRGGTESD	LTVSRLAPSH	QASPLAPAFE	GDGYYLAMGG
AVAQHNWSHI	TTVLQDQKSQ	CQLIDSSEDL	GMISIQGPAS	RAILQEVLDA
DLSNEAFPFS	THKLLRAAGH	LVRAMRLSFV	GELGWELHIP	KASCVPVYRA
VMAAGAKHGL	INAGYRAIDS	LSIEKGYRHW	HADLRPDDSP	LEAGLAFTCK
LKSPVPFLGR	EALEQQRAAG	LRRRLVCFTM	EDKVPMFGLE	AIWRNGQVVG
HVRRADFGFA	IDKTIAYGYI	HDPSGGPVSL	DFVKSGDYAL	ERMGVTYGAQ
AHLKSPFDPN	NKRVKGIY

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123453 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009614 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.
^ "Entrez Gene: SARDH sarcosine dehydrogenase".
^ "UniProt, Q9UL12". Pristupljeno 11. 9. 2021.

Dopunska literatura uredi

Porter DH, Cook RJ, Wagner C (1986). "Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver". Arch. Biochem. Biophys. 243 (2): 396–407. doi:10.1016/0003-9861(85)90516-8. PMID 2417560.
London RE, Gabel SA, Funk A (1988). "Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study". Biochemistry. 26 (22): 7166–72. doi:10.1021/bi00396a044. PMID 2447942.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bergeron F, Otto A, Blache P, et al. (1998). "Molecular cloning and tissue distribution of rat sarcosine dehydrogenase". Eur. J. Biochem. 257 (3): 556–61. doi:10.1046/j.1432-1327.1998.2570556.x. PMID 9839943.
Gilbert JR, Kumar A, Newey S, et al. (2000). "Physical and cDNA mapping in the DBH region of human chromosome 9q34". Hum. Hered. 50 (3): 151–7. doi:10.1159/000022905. PMID 10686491. S2CID 43238824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123453 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009614 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10444331-5] Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.

[entrez-6] "Entrez Gene: SARDH sarcosine dehydrogenase".

[UniProt-7] "UniProt, Q9UL12". Pristupljeno 11. 9. 2021.

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