Razlika između verzija stranice "Diobeno vreteno"

TheKompletnuformaciju completiondiobenog ofvretena spindleuglavnom formationkontrolira istranzicijska atačka crucialu transition[[ćelijski pointciklus|ćelijskom inciklusu]], thezvana cellkontrolna cycletačka calleddiobenog thevretena [[(''spindle assembly checkpoint]]''). IfAko someneki chromosomeshromosom arenije notodgovarajuće properlyprikačen attachedna tovreteno theovaj mitotickontrolor spindleće by the time of this checkpoint, the onset ofga anaphasespustiti willpri bekraju delayedanafaze.<ref name="Raven">{{cite book | last = Raven | first = Peter H. |author2=Ray F. Evert |author3=Susan E. Eichhorn | title = Biology of Plants, 7th Edition | publisher = W.H. Freeman and Company Publishers | year = 2005 | location = New York | pages = 59 | isbn = 0-7167-1007-2}}</ref> FailureGreške ofu thisovom spindle"čekpointu" assemblymogu checkpointrezultirati can result inpojavom [[aneuploidyAneuploidija|aneuploidije]] andi maymože bebiti involveduključen inu agingstarenje andi thestvaranje formation of cancer[rak|kancera]].<ref name="pmid16226453">{{citeNenormalna journaldiobena |author=Bakervretena DJ,produciraju Chen J, van Deursen JMtripolarne [[mitoza|title=The mitotic checkpoint in cancer and aging: what have mice taught us? |journal=Currmitoze]]. Opin.Ovo Cellsu Biol.jasno |volume=17nenormalni |issue=6slučajevi |pages=583–9i |year=2005mogu |pmid=16226453uzrokovati |doi=10.1016/j.ceb.2005.09.011}}</ref>tumore, Abnormalmeđu mitoticnjima spindlesi can produce tripolar mitosismaligne. TheseTakve areabnormalnosti clearly abnormal cases andse, if presentmeđutim, are consideredčesto definitiveistražuju evidenceu thathistopatološkoj aanalizi tumori is malignant rather than benign. Such abnormalities are therefore often searched for in histological assays by pathologists when evaluating the potential malignancy ofprocjeni amaligniteta tumortumorske massmase.