Obestatin

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Preprohormon grelin/obestatina
Preprohormon grelin/obestatina
	NMR struktura obestatina u SDS / DPC micelnom rastvoru.
Identifikatori
Simbol	?
NCBI gen	51738
HGNC	18129
OMIM	605353
RefSeq	NM_016362
UniProt	Q9UBU3
Ostali podaci
Lokus	Hrom. 3 p26-p25
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

Obestatin je hormon koji se proizvodi u specijaliziranim epitelnim stanicama želuca i tankog crijeva nekoliko životinja, i kod čovjeka.^[2] Obestatin je prvobitno identificiran kao anorektični peptid, ali njegov učinak na unos hrane ostaje kontroverzan.^[3]

Otkriće

Obestatin je otkriven korištenjem bioinformatičkog pristupa: računarskom pretragom sekvenciranih genoma nekoliko organizama.^[4]

Također pogledajte

Reference

^ PDB 2JSH; Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM (novembar 2007). "Obestatin conformational features: a strategy to unveil obestatin's biological role?". Biochem. Biophys. Res. Commun. 363 (3): 500–5. doi:10.1016/j.bbrc.2007.08.200. PMID 17904104.CS1 održavanje: više imena: authors list (link)
^ "Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?". Regul. Pept. 141 (1–3): 1–7. juni 2007. doi:10.1016/j.regpep.2006.12.023. PMID 17321609.
^ "The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake". J. Neuroendocrinol. 22 (7): 793–804. juli 2010. doi:10.1111/j.1365-2826.2010.02019.x. PMID 20456603.
^ "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science. 310 (5750): 996–9. novembar 2005. Bibcode:2005Sci...310..996Z. doi:10.1126/science.1117255. PMID 16284174.

Dodatna literatura

Holst B, Egerod KL, Schild E; et al. (2007). "GPR39 signaling is stimulated by zinc ions but not by obestatin". Endocrinology. 148 (1): 13–20. doi:10.1210/en.2006-0933. PMID 16959833. Eksplicitna upotreba et al. u: |author= (pomoć)CS1 održavanje: više imena: authors list (link)
Obestatin, novi fiziološki oponent grelina

Vanjski linkovi

obestatin, human na US National Library of Medicine Medical Subject Headings (MeSH)

[pmid17904104-1] PDB 2JSH; Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM (novembar 2007). "Obestatin conformational features: a strategy to unveil obestatin's biological role?". Biochem. Biophys. Res. Commun. 363 (3): 500–5. doi:10.1016/j.bbrc.2007.08.200. PMID 17904104.CS1 održavanje: više imena: authors list (link)

[pmid173216092-2] "Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?". Regul. Pept. 141 (1–3): 1–7. juni 2007. doi:10.1016/j.regpep.2006.12.023. PMID 17321609.

[pmid204566032-3] "The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake". J. Neuroendocrinol. 22 (7): 793–804. juli 2010. doi:10.1111/j.1365-2826.2010.02019.x. PMID 20456603.

[pmid162841742-4] "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science. 310 (5750): 996–9. novembar 2005. Bibcode:2005Sci...310..996Z. doi:10.1126/science.1117255. PMID 16284174.

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