MT1G

Metalotionein-1G je protein koji je kod ljudi kodiran genom MT1G.

MT1G
Identifikatori
Aliasi	MT1G
Vanjski ID-jevi	OMIM: 156353 GeneCards: MT1G
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16q13 Početak 56,666,730 bp Kraj 56,668,065 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona cinka • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala Ćelijska komponenta • citoplazma • perinuklearno područje citoplazme • jedro Biološki proces • monocyte activation • cellular response to copper ion • cellular response to vascular endothelial growth factor stimulus • negative regulation of growth • cellular response to cadmium ion • monocyte differentiation • cellular response to zinc ion • cellular zinc ion homeostasis • detoxification of copper ion Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4495	n/a
Ensembl	ENSG00000125144	n/a
UniProt	P13640	n/a
RefSeq (mRNK)	NM_005950 NM_001301267	n/a
RefSeq (bjelančevina)	NP_001288196 NP_005941	n/a
Lokacija (UCSC)	Chr 16: 56.67 – 56.67 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 62 aminokiseline, a molekulska težina 6.141 Da.

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MDPNCSCAAA		GVSCTCASSC		KCKECKCTSC		KKSCCSCCPV		GCAKCAQGCI
CKGASEKCSC		CA

Dopunska literatura

• West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
• Gedamu L, Varshney U, Jahroudi N, et al. (1987). "Structure and expression of the human metallothionein genes". Metallothionein II. Experientia Supplementum. 52. str. 361–72. doi:10.1007/978-3-0348-6784-9_34. ISBN 978-3-0348-6786-3. PMID 2444457.
• Varshney U, Jahroudi N, Foster R, Gedamu L (1987). "Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids". Mol. Cell. Biol. 6 (1): 26–37. doi:10.1128/MCB.6.1.26. PMC 367480. PMID 3023827.
• Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Huang Y, de la Chapelle A, Pellegata NS (2003). "Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma". Int. J. Cancer. 104 (6): 735–44. doi:10.1002/ijc.11006. PMID 12640681. S2CID 26461955.
• Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene". World J. Gastroenterol. 9 (9): 1892–6. doi:10.3748/wjg.v9.i9.1892. PMC 4656638. PMID 12970870.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762.
• Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.