MIR146A

MikroRNK 146a jest mala nekodirajuća RNK koja je kod ljudi kodirana genom MIR146A sa hromosoma 5.

MIR146A
Identifikatori
Aliasi	MIR146A
Vanjski ID-jevi	OMIM: 610566 GeneCards: MIR146A
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q33.3 Početak 160,485,352 bp Kraj 160,485,450 bp
Ortolozi
Vrste	Čovjek	Miš
Entrez	406938	n/a
Ensembl	ENSG00000283733	n/a
UniProt	n a	n/a
RefSeq (mRNK)	n/a	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	Chr 5: 160.49 – 160.49 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

mikroRNK (miRNK) su kratke (20-24 nt) nekodirajuće RNK koje su uključene u posttranskripcijsku regulaciju ekspresije gena u višećelijskim organizmima, utičući i na stabilnost i na translaciju iRNK. miRNK se transkribira RNK-polimerazom II, kao dio kapiranih i poliadeniliranih primarnih transkripata (pri-miRNK), koji mogu biti protein-kodirajući ili nekodirajući. Primarni transkript se cijepa enzimom Drosha (ribonukleaza III), kako bi se proizvela približno 70-nt prekursorska miRNK iz matične petlje (pre-miRNK), koja se dalje cijepa citoplazmatskom Dicer ribonukleazom, kako bi nastali proizvodi: zrela miRNK i antisens miRNK sa zjezdomvi (miRNK*). Zrela miRNK ugrađena je u kompleks za utišavanje induciran RNK (RISC), koji prepoznaje ciljane mRNK, preko nesavršenog uparivanja baze s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljane iRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK.

Dopunska literatura

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