Mitogen–aktivirana protein-kinaza 1, znana i kao MAPK1, p42MAPK i ERK2, jest enzim koji je kod ljudi kodiran genom sa MAPK1 hromosoma 22.[5]

MAPK1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I

Identifikatori
AliasiMAPK1
Vanjski ID-jeviOMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1
Lokacija gena (čovjek)
Hromosom 22 (čovjek)
Hrom.Hromosom 22 (čovjek)[1]
Hromosom 22 (čovjek)
Genomska lokacija za MAPK1
Genomska lokacija za MAPK1
Bend22q11.22Početak21,759,657 bp[1]
Kraj21,867,680 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za MAPK1
Genomska lokacija za MAPK1
Bend16 A3|16 10.53 cMPočetak16,801,246 bp[2]
Kraj16,865,317 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija phosphatase binding
ATP binding
protein kinase activity
transcription factor binding
transferase activity
mitogen-activated protein kinase kinase kinase binding
phosphotyrosine residue binding
GO:0001948, GO:0016582 protein binding
protein kinase binding
DNA binding
nucleotide binding
RNA polymerase II CTD heptapeptide repeat kinase activity
protein serine/threonine kinase activity
kinase activity
identical protein binding
MAP kinase activity
double-stranded DNA binding
MAP kinase kinase activity
Ćelijska komponenta citoplazma
citosol
focal adhesion
centar organizacije mikrotubula
mitohondrija
Kaveole
dendrite cytoplasm
citoskelet
Jedro
Egzosom
perikaryon
late endosome
Golđijev aparat
Diobeno vreteno
Akson
early endosome
mitotic spindle
Pseudopodija
extracellular region
Nukleoplazma
azurophil granule lumen
ficolin-1-rich granule lumen
Ćelijska membrana
GO:0097483, GO:0097481 postsynaptic density
membrana
GO:0009327 protein-containing complex
Biološki proces caveolin-mediated endocytosis
positive regulation of telomere capping
response to exogenous dsRNA
cardiac neural crest cell development involved in heart development
positive regulation of translation
cellular response to DNA damage stimulus
platelet activation
Fc-epsilon receptor signaling pathway
protein phosphorylation
face development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
regulation of DNA-binding transcription factor activity
animal organ morphogenesis
Ćelijski ciklus
ERBB signaling pathway
GO:0097285 Apoptoza
B cell receptor signaling pathway
GO:0009373 regulation of transcription, DNA-templated
regulation of protein stability
Fc-gamma receptor signaling pathway involved in phagocytosis
thymus development
negative regulation of cell differentiation
ERK1 and ERK2 cascade
labyrinthine layer blood vessel development
transcription, DNA-templated
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
heart development
GO:0022415 viral process
response to toxic substance
regulation of stress-activated MAPK cascade
chemical synaptic transmission
growth hormone receptor signaling pathway via JAK-STAT
cytosine metabolic process
Fosforilacija
outer ear morphogenesis
response to estrogen
Hemotaksija
response to lipopolysaccharide
thyroid gland development
response to epidermal growth factor
positive regulation of telomerase activity
Nocicepcija
peptidyl-threonine phosphorylation
trachea formation
lipopolysaccharide-mediated signaling pathway
mammary gland epithelial cell proliferation
GO:0007243 intracellular signal transduction
lung morphogenesis
neural crest cell development
positive regulation of cell migration
regulation of early endosome to late endosome transport
response to stress
positive regulation of telomere maintenance via telomerase
MAPK cascade
axon guidance
fibroblast growth factor receptor signaling pathway
positive regulation of peptidyl-threonine phosphorylation
GO:0035404 peptidyl-serine phosphorylation
positive regulation of cell population proliferation
regulation of cellular response to heat
Bergmann glial cell differentiation
regulation of Golgi inheritance
T cell receptor signaling pathway
regulation of cytoskeleton organization
GO:0072468 Transdukcija signala
long-term potentiation
regulation of ossification
regulation of phosphatidylinositol 3-kinase signaling
neutrophil degranulation
Regulacija ekspresije gena
cellular response to organic substance
GO:0010260 Starenje
learning or memory
GO:1901313 positive regulation of gene expression
diadenosine tetraphosphate biosynthetic process
regulation of cellular pH
cellular response to amino acid starvation
GO:0072353 cellular response to reactive oxygen species
response to nicotine
decidualization
stress-activated MAPK cascade
positive regulation of cardiac muscle cell proliferation
cellular response to cadmium ion
cellular response to tumor necrosis factor
cellular response to dopamine
positive regulation of protein import into nucleus
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_138957
NM_002745

NM_001038663
NM_011949
NM_001357115
NM_028991

RefSeq (bjelančevina)

NP_002736
NP_620407

NP_001033752
NP_036079
NP_001344044

Lokacija (UCSC)Chr 22: 21.76 – 21.87 MbChr 16: 16.8 – 16.87 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 360 aminokiselina, a molekulska težina 41.390 Da.

1020304050
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVR
VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKD
VYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDL
KPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML
NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE
DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEE
TARFQPGYRS

Funkcija uredi

Protein kodiran ovim genom član je porodice MAP-kinaza. MAP-kinaze, također poznate kao vanćelijske signalno regulirane kinaze (ERK), djeluju kao integracijska tačka za više biohemijskih signala i uključene su u širok spektar ćelijskih procesa, kao što je proliferacija, diferencijacija, regulacija i razvoj transkripcije. Aktivacija ove kinaze zahtijeva njenu fosforilaciju uzvodnim kinazama. Nakon aktivacije, ova kinaza translocira se u jedro stimuliranih ćelija, gdje fosforilira jedarne mete. Za ovaj gen prijavljene su dvije alternativno prerađene varijante transkripta koje kodiraju isti protein, ali se razlikuju u UTR-u.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]

Modelni organizmi uredi

U proučavanju funkcije MAPK1 korišteni su modelni organizmi. Uslovna linija nokaut-miša, zvana Mapk1tm1a(EUCOMM)Wtsi[8][9] generirana je kao dio programa Konzorcija za nokaut-miševe—projekta mutageneze visoke propusnosti za generiranje i distribuciju životinjskih modela bolesti zainteresiranim naučnicima.[10][11][12]

Fenotip Mapk1 nokaut-miševa
Svojstvo Fenotip
Vijabilnost homozigota Nenormalan
Studija recesivne letalnosti Nenormalan
Plodnost Normalan
Tjelesna težina Normalan
Anksioznost otvorenog polja| Normalan
Neurološka procjena Normalan
Snaga ugriza Normalan
Test vruće ploče Normalan
Dismorfologija Normalan [13]
Indirektna kalorimetrija Normalan
Test tolerancije glukoze Normalan
Slušni odgovor moždanog stabla Normalan
DEXA Normalan
Radiografija Normalan
Tjelesna temperatura Normalan
Morfologija OKA Normalan
klinička hemija Nenormalan[14]
Plazmatski imunoglobulini Normalan
Hematologija Normalan
Leukociti periferne krvi Normalan
Mikronukleus test Normalan
Težina srca Normalan
Cjelovitost repne epiderme Normalan
Histopatologija kože Normalan
Histopatologija mozga Normalan
Salmonella infekcija Normalan[15]
Citrobacter infekcija Normalan[16]
Svi testovi i analize su prema[17][18]

Mužjaci i ženke su podvrgnute standardiziranom fenotipskom pregledu, kako bi se utvrdili efekti deleciija.[17][19] Obavljeno je 27 testova na mutantnim miševima i uočene su tri značajne abnormalnosti.[17] Nijedan homozigotni mutantni embrion nije identifikovan tokom gestacije, pa stoga nijedan nije preživio do odbijanja. Preostali testovi su obavljeni na heterozigotnim mutantnim odraslim miševima, a mužjaci su imali smanjene razine amilaze u cirkulaciji.[17]

Uslovna delecija "Mapk1" u B-ćelijama pokazala je ulogu MAPK1 u proizvodnji antitijela zavisnih od T-ćelija.[20] Dominantni mutanti za dobijanje funkcije "Mapk1" kod transgenih miševa pokazao je ulogu MAPK1 u razvoju T-ćelija.[21] Uslovna inaktivacija "Mapk1" u nervnim progenitorskim ćelijama korteksa u razvoju dovodi do smanjenja debljine korteksa i smanjene proliferacije u nervnim progenitorskim ćelijama.[22]

Interakcije uredi

Pokazalo se da MAPK1 reaguje sa:

Klinički značaj uredi

Mutacije u MAPK1 su uključene u mnoge tipove kancera.[61]

Također pogledajte uredi

Reference uredi

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