HCST

Pretvarač signala hematopoetskih ćelija ili tranduktor signala hematopoetskih signala je protein koji je dod ljudi kodiran genom HCST.

HCST
Identifikatori
Aliasi	HCST
Vanjski ID-jevi	OMIM: 604089 MGI: 1344360 HomoloGene: 8024 GeneCards: HCST
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.12 Početak 35,902,529 bp Kraj 35,904,377 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7 B1|7 17.45 cM Početak 30,117,137 bp Kraj 30,119,279 bp
Ontologija gena Molekularna funkcija • signaling receptor binding • GO:0001948, GO:0016582 vezivanje za proteine • phosphatidylinositol 3-kinase binding Ćelijska komponenta • integral component of membrane • cell surface • ćelijska membrana • membrana Biološki proces • protein phosphorylation • regulation of immune response • positive regulation of phosphatidylinositol 3-kinase signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10870	23900
Ensembl	ENSG00000126264	ENSMUSG00000064109
UniProt	Q9UBK5	Q9QUJ0
RefSeq (mRNK)	NM_014266 NM_001007469	NM_011827
RefSeq (bjelančevina)	NP_001007470 NP_055081	NP_035957
Lokacija (UCSC)	Chr 19: 35.9 – 35.9 Mb	Chr 7: 30.12 – 30.12 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira transmembranski signalni adapter koji sadrži YxxM motiv u svojoj citoplazmatskom domenu. Kodirani protein može činiti dio kompleksa receptora imunskog prepoznavanja sa receptorom sličnim lektinu C tipa NKG2D. Kao dio ovog receptorskog kompleksa, ovaj protein može aktivirati signalne puteve ovisne o fosfatidilinozitol 3-kinazi, preko svog intracitoplazmatskog motiva YxxM.

Ovaj receptorski kompleks može imati ulogu u preživljavanju i proliferaciji ćelija, aktivacijom odgovora NK i T-ćelija. Alternativna prerada rezultira u dvije varijante transkripta, koji kodiraju različite izoforme.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MIHLGHILFL		LLLPVAAAQT		TPGERSSLPA		FYPGTSGSCS		GCGSLSLPLL
AGLVAADAVA		SLLIVGAVFL		CARPRRSPAQ		EDGKVYINMP		GRG

Dopunska literatura

• Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells". J. Immunol. 175 (12): 7819–28. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
• André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors". Eur. J. Immunol. 34 (4): 961–71. doi:10.1002/eji.200324705. PMID 15048706.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nat. Immunol. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
• Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
• Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D". Immunogenetics. 53 (3): 243–9. doi:10.1007/s002510100321. PMID 11398969. S2CID 23708388.
• Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
• Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells". J. Exp. Med. 192 (7): 1059–68. doi:10.1084/jem.192.7.1059. PMC 2193316. PMID 11015446.
• Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4. PMID 10528161.