INTS11

INTS11
Identifikatori
Aliasi	INTS11
Vanjski ID-jevi	OMIM: 611354 MGI: 1919207 HomoloGene: 9894 GeneCards: INTS11
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	1,324,687 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	155,973,560 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hydrolase activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• blood microparticle; • integrator complex; • nukleoplazma; • citosol; • jedro; • citoplazma;
Biološki proces	• snRNA processing; • snRNA transcription by RNA polymerase II; • snRNA 3'-end processing; • regulation of RNA splicing;
	Izvori:Amigo / QuickGO
Ortolozi
	54973
	71957
	ENSG00000127054
	ENSMUSG00000029034
	Q5TA45
	Q9CWS4
NM_001256456; NM_001256460; NM_001256462; NM_001256463; NM_017871;
	NM_032179
	NM_028020
	NP_001243385; NP_001243389; NP_001243391; NP_001243392; NP_060341
	NP_082296
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 11 integratorskog kompleksa jest protein koji je kod ljudi kodiran genom CPSF3L sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 600 aminokiselina, a molekulska težina 67.663 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPEIRVTPLG	AGQDVGRSCI	LVSIAGKNVM	LDCGMHMGFN	DDRRFPDFSY
ITQNGRLTDF	LDCVIISHFH	LDHCGALPYF	SEMVGYDGPI	YMTHPTQAIC
PILLEDYRKI	AVDKKGEANF	FTSQMIKDCM	KKVVAVHLHQ	TVQVDDELEI
KAYYAGHVLG	AAMFQIKVGS	ESVVYTGDYN	MTPDRHLGAA	WIDKCRPNLL
ITESTYATTI	RDSKRCRERD	FLKKVHETVE	RGGKVLIPVF	ALGRAQELCI
LLETFWERMN	LKVPIYFSTG	LTEKANHYYK	LFIPWTNQKI	RKTFVQRNMF
EFKHIKAFDR	AFADNPGPMV	VFATPGMLHA	GQSLQIFRKW	AGNEKNMVIM
PGYCVQGTVG	HKILSGQRKL	EMEGRQVLEV	KMQVEYMSFS	AHADAKGIMQ
LVGQAEPESV	LLVHGEAKKM	EFLKQKIEQE	LRVNCYMPAN	GETVTLPTSP
SIPVGISLGL	LKREMAQGLL	PEAKKPRLLH	GTLIMKDSNF	RLVSSEQALK
ELGLAEHQLR	FTCRVHLHDT	RKEQETALRV	YSHLKSVLKD	HCVQHLPDGS
VTVESVLLQA	AAPSEDPGTK	VLLVSWTYQD	EELGSFLTSL	LKKGLPQAPS

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127054 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029034 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF (Feb 2005). "A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100". Mol Cell Biol. 25 (4): 1489–500. doi:10.1128/MCB.25.4.1489-1500.2005. PMC 548002. PMID 15684398.
^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
^ "Entrez Gene: CPSF3L cleavage and polyadenylation specific factor 3-like".
^ "UniProt, Q5TA45" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura uredi

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

Vanjski linkovi uredi

Lokacija ljudskog genoma CPSF3L i stranica sa detaljima o genu CPSF3L u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127054 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029034 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15684398-5] Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF (Feb 2005). "A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100". Mol Cell Biol. 25 (4): 1489–500. doi:10.1128/MCB.25.4.1489-1500.2005. PMC 548002. PMID 15684398.

[pmid16239144-6] Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.

[entrez-7] "Entrez Gene: CPSF3L cleavage and polyadenylation specific factor 3-like".

[UniProt-8] "UniProt, Q5TA45" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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