GMDS

GMDS
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1T2A
Identifikatori
Aliasi	GMDS
Vanjski ID-jevi	OMIM: 602884 MGI: 1891112 HomoloGene: 75968 GeneCards: GMDS
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	2,245,605 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	32,522,723 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • NADP+ binding; • lyase activity; • GDP-mannose 4,6-dehydratase activity; • vezivanje identičnih proteina;
Ćelijska komponenta	• citosol; • Egzosom; • citoplazma;
Biološki proces	• GDP-mannose metabolic process; • 'de novo' GDP-L-fucose biosynthetic process; • Notch signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	2762
	218138
	ENSG00000112699
	ENSMUSG00000038372
	O60547
	Q8K0C9
	NM_001253846; NM_001500
	NM_146041
	NP_001240775; NP_001491
	NP_666153
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

GDP-manozna 4,6 dehidrataza jest enzim koji je kod ljudi kodiran genom GMDS.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 372 aminokiseline, а molekulska težina 41.950 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAHAPARCPS	ARGSGDGEMG	KPRNVALITG	ITGQDGSYLA	EFLLEKGYEV
HGIVRRSSSF	NTGRIEHLYK	NPQAHIEGNM	KLHYGDLTDS	TCLVKIINEV
KPTEIYNLGA	QSHVKISFDL	AEYTADVDGV	GTLRLLDAVK	TCGLINSVKF
YQASTSELYG	KVQEIPQKET	TPFYPRSPYG	AAKLYAYWIV	VNFREAYNLF
AVNGILFNHE	SPRRGANFVT	RKISRSVAKI	YLGQLECFSL	GNLDAKRDWG
HAKDYVEAMW	LMLQNDEPED	FVIATGEVHS	VREFVEKSFL	HIGKTIVWEG
KNENEVGRCK	ETGKVHVTVD	LKYYRPTEVD	FLQGDCTKAK	QKLNWKPRVA
FDELVREMVH	ADVELMRTNP	NA

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112699 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038372 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA (maj 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".
^ "UniProt, O60547" (jezik: engleski). Pristupljeno 2. 10. 2021.

Dopunska literatura

Ohyama C, Smith PL, Angata K, et al. (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi:10.1074/jbc.273.23.14582. PMID 9603974.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi:10.1074/jbc.M107927200. PMID 11698403.
Eshel R, Besser M, Zanin A, et al. (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID 11831876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112699 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038372 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9525924-5] Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA (maj 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-7] "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

[UniProt-8] "UniProt, O60547" (jezik: engleski). Pristupljeno 2. 10. 2021.

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