UBR4
(Preusmjereno sa E3 ubikvitin-protein ligaza 4)
E3 ubikvitin-protein ligaza UBR4 jest enzim koji je kod ljudi kodiran genom UBR4 sa hromosoma 1.[5][6][7][8]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 5.183 aminokiselina, a molekulska težina 573.841 Da.[9]
10 | 20 | 30 | 40 | 50 | ||||
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MATSGGEEAA | AAAPAPGTPA | TGADTTPGWE | VAVRPLLSAS | YSAFEMKELP | ||||
QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV | ||||
AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT | ||||
FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV | ||||
FNPRTVASQP | ISTQTLVEGE | NDEQSSTDQA | SAIKTKNVFI | AQNVASLQEL | ||||
GGSEKLLRVC | LNLPYFLRYI | NRFQDAVLAN | SFFIMPATVA | DATAVRNGFH | ||||
SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL | ||||
HVGSAQQVRT | GSTSSKEDDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG | ||||
EHYQNFQLLG | AWCLLNSLFL | ILNLSPTALA | DKGKEKDPLA | ALRVRDILSR | ||||
TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLTSLFQD | LQVEALHKGW | ||||
ETDGPPAALS | IMAQSTSIQR | IQRLIDSVPL | MNLLLTLLST | SYRKACVLQR | ||||
QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS | ||||
PSKEKAAPPP | PPPPPPLESS | PRVKSPSKQA | PGEKGNILAS | RKDPELFLGL | ||||
ASNILNFITS | SMLNSRNNFI | RNYLSVSLSE | HHMATLASII | KEVDKDGLKG | ||||
SSDEEFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPF | SEGPWPLYIH | ||||
PQSLSVLSRL | LLIWQHKASA | QGDPDVPECL | KVWDRFLSTM | KQNALQGVVP | ||||
SETEDLNVEH | LQMLLLIFHN | FTETGRRAIL | SLFVQIIQEL | SVNMDAQMRF | ||||
VPLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSNS | ||||
RRATTPLYHG | FKEVEENWSK | HFSSDAVPHP | RFYCVLSPEA | SEDDLNRLDS | ||||
VACDVLFSKL | VKYDELYAAL | TALLAAGSQL | DTVRRKENKN | VTALEACALQ | ||||
YYFLILWRIL | GILPPSKTYI | NQLSMNSPEM | SECDILHTLR | WSSRLRISSY | ||||
VNWIKDHLIK | QGMKAEHASS | LLELASTTKC | SSVKYDVEIV | EEYFARQISS | ||||
FCSIDCTTIL | QLHEIPSLQS | IYTLDAAISK | VQVSLDEHFS | KMAAETDPHK | ||||
SSEITKNLLP | ATLQLIDTYA | SFTRAYLLQN | FNEEGTTEKP | SKEKLQGFAA | ||||
VLAIGSSRCK | ANTLGPTLVQ | NLPSSVQTVC | ESWNNINTNE | FPNIGSWRNA | ||||
FANDTIPSES | YISAVQAAHL | GTLCSQSLPL | AASLKHTLLS | LVRLTGDLIV | ||||
WSDEMNPPQV | IRTLLPLLLE | SSTESVAEIS | SNSLERILGP | AESDEFLARV | ||||
YEKLITGCYN | ILANHADPNS | GLDESILEEC | LQYLEKQLES | SQARKAMEEF | ||||
FSDSGELVQI | MMATANENLS | AKFCNRVLKF | FTKLFQLTEK | SPNPSLLHLC | ||||
GSLAQLACVE | PVRLQAWLTR | MTTSPPKDSD | QLDVIQENRQ | LLQLLTTYIV | ||||
RENSQVGEGV | CAVLLGTLTP | MATEMLANGD | GTGFPELMVV | MATLASAGQG | ||||
AGHLQLHNAA | VDWLSRCKKY | LSQKNVVEKL | NANVMHGKHV | MILECTCHIM | ||||
SYLADVTNAL | SQSNGQGPSH | LSVDGEERAI | EVDSDWVEEL | AVEEEDSQAE | ||||
DSDEDSLCNK | LCTFTITQKE | FMNQHWYHCH | TCKMVDGVGV | CTVCAKVCHK | ||||
DHEISYAKYG | SFFCDCGAKE | DGSCLALVKR | TPSSGMSSTM | KESAFQSEPR | ||||
ISESLVRHAS | TSSPADKAKV | TISDGKVADE | EKPKKSSLCR | TVEGCREELQ | ||||
NQANFSFAPL | VLDMLNFLMD | AIQTNFQQAS | AVGSSSRAQQ | ALSELHTVEK | ||||
AVEMTDQLMV | PTLGSQEGAF | ENVRMNYSGD | QGQTIRQLIS | AHVLRRVAMC | ||||
VLSSPHGRRQ | HLAVSHEKGK | ITVLQLSALL | KQADSSKRKL | TLTRLASAPV | ||||
PFTVLSLTGN | PCKEDYLAVC | GLKDCHVLTF | SSSGSVSDHL | VLHPQLATGN | ||||
FIIKAVWLPG | SQTELAIVTA | DFVKIYDLCV | DALSPTFYFL | LPSSKIRDVT | ||||
FLFNEEGKNI | IVIMSSAGYI | YTQLMEEASS | AQQGPFYVTN | VLEINHEDLK | ||||
DSNSQVAGGG | VSVYYSHVLQ | MLFFSYCQGK | SFAATISRTT | LEVLQLFPIN | ||||
IKSSNGGSKT | SPALCQWSEV | MNHPGLVCCV | QQTTGVPLVV | MVKPDTFLIQ | ||||
EIKTLPAKAK | IQDMVAIRHT | ACNEQQRTTM | ILLCEDGSLR | IYMANVENTS | ||||
YWLQPSLQPS | SVISIMKPVR | KRKTATITTR | TSSQVTFPID | FFEHNQQLTD | ||||
VEFGGNDLLQ | VYNAQQIKHR | LNSTGMYVAN | TKPGGFTIEI | SNNNSTMVMT | ||||
GMRIQIGTQA | IERAPSYIEI | FGRTMQLNLS | RSRWFDFPFT | REEALQADKK | ||||
LNLFIGASVD | PAGVTMIDAV | KIYGKTKEQF | GWPDEPPEEF | PSASVSNICP | ||||
SNLNQSNGTG | DSDSAAPTTT | SGTVLERLVV | SSLEALESCF | AVGPIIEKER | ||||
NKNAAQELAT | LLLSLPAPAS | VQQQSKSLLA | SLHTSRSAYH | SHKDQALLSK | ||||
AVQCLNTSSK | EGKDLDPEVF | QRLVITARSI | AIMRPNNLVH | FTESKLPQME | ||||
TEGMDEGKEP | QKQLEGDCCS | FITQLVNHFW | KLHASKPKNA | FLAPACLPGL | ||||
THIEATVNAL | VDIIHGYCTC | ELDCINTASK | IYMQMLLCPD | PAVSFSCKQA | ||||
LIRVLRPRNK | RRHVTLPSSP | RSNTPMGDKD | DDDDDDADEK | MQSSGIPNGG | ||||
HIRQESQEQS | EVDHGDFEMV | SESMVLETAE | NVNNGNPSPL | EALLAGAEGF | ||||
PPMLDIPPDA | DDETMVELAI | ALSLQQDQQG | SSSSALGLQS | LGLSGQAPSS | ||||
SSLDAGTLSD | TTASAPASDD | EGSTAATDGS | TLRTSPADHG | GSVGSESGGS | ||||
AVDSVAGEHS | VSGRSSAYGD | ATAEGHPAGP | GSVSSSTGAI | STTTGHQEGD | ||||
GSEGEGEGET | EGDVHTSNRL | HMVRLMLLER | LLQTLPQLRN | VGGVRAIPYM | ||||
QVILMLTTDL | DGEDEKDKGA | LDNLLSQLIA | ELGMDKKDVS | KKNERSALNE | ||||
VHLVVMRLLS | VFMSRTKSGS | KSSICESSSL | ISSATAAALL | SSGAVDYCLH | ||||
VLKSLLEYWK | SQQNDEEPVA | TSQLLKPHTT | SSPPDMSPFF | LRQYVKGHAA | ||||
DVFEAYTQLL | TEMVLRLPYQ | IKKITDTNSR | IPPPVFDHSW | FYFLSEYLMI | ||||
QQTPFVRRQV | RKLLLFICGS | KEKYRQLRDL | HTLDSHVRGI | KKLLEEQGIF | ||||
LRASVVTASS | GSALQYDTLI | SLMEHLKACA | EIAAQRTINW | QKFCIKDDSV | ||||
LYFLLQVSFL | VDEGVSPVLL | QLLSCALCGS | KVLAALAASS | GSSSASSSSA | ||||
PVAASSGQAT | TQSKSSTKKS | KKEEKEKEKD | GETSGSQEDQ | LCTALVNQLN | ||||
KFADKETLIQ | FLRCFLLESN | SSSVRWQAHC | LTLHIYRNSS | KSQQELLLDL | ||||
MWSIWPELPA | YGRKAAQFVD | LLGYFSLKTP | QTEKKLKEYS | QKAVEILRTQ | ||||
NHILTNHPNS | NIYNTLSGLV | EFDGYYLESD | PCLVCNNPEV | PFCYIKLSSI | ||||
KVDTRYTTTQ | QVVKLIGSHT | ISKVTVKIGD | LKRTKMVRTI | NLYYNNRTVQ | ||||
AIVELKNKPA | RWHKAKKVQL | TPGQTEVKID | LPLPIVASNL | MIEFADFYEN | ||||
YQASTETLQC | PRCSASVPAN | PGVCGNCGEN | VYQCHKCRSI | NYDEKDPFLC | ||||
NACGFCKYAR | FDFMLYAKPC | CAVDPIENEE | DRKKAVSNIN | TLLDKADRVY | ||||
HQLMGHRPQL | ENLLCKVNEA | APEKPQDDSG | TAGGISSTSA | SVNRYILQLA | ||||
QEYCGDCKNS | FDELSKIIQK | VFASRKELLE | YDLQQREAAT | KSSRTSVQPT | ||||
FTASQYRALS | VLGCGHTSST | KCYGCASAVT | EHCITLLRAL | ATNPALRHIL | ||||
VSQGLIRELF | DYNLRRGAAA | MREEVRQLMC | LLTRDNPEAT | QQMNDLIIGK | ||||
VSTALKGHWA | NPDLASSLQY | EMLLLTDSIS | KEDSCWELRL | RCALSLFLMA | ||||
VNIKTPVVVE | NITLMCLRIL | QKLIKPPAPT | SKKNKDVPVE | ALTTVKPYCN | ||||
EIHAQAQLWL | KRDPKASYDA | WKKCLPIRGI | DGNGKAPSKS | ELRHLYLTEK | ||||
YVWRWKQFLS | RRGKRTSPLD | LKLGHNNWLR | QVLFTPATQA | ARQAACTIVE | ||||
ALATIPSRKQ | QVLDLLTSYL | DELSIAGECA | AEYLALYQKL | ITSAHWKVYL | ||||
AARGVLPYVG | NLITKEIARL | LALEEATLST | DLQQGYALKS | LTGLLSSFVE | ||||
VESIKRHFKS | RLVGTVLNGY | LCLRKLVVQR | TKLIDETQDM | LLEMLEDMTT | ||||
GTESETKAFM | AVCIETAKRY | NLDDYRTPVF | IFERLCSIIY | PEENEVTEFF | ||||
VTLEKDPQQE | DFLQGRMPGN | PYSSNEPGIG | PLMRDIKNKI | CQDCDLVALL | ||||
EDDSGMELLV | NNKIISLDLP | VAEVYKKVWC | TTNEGEPMRI | VYRMRGLLGD | ||||
ATEEFIESLD | STTDEEEDEE | EVYKMAGVMA | QCGGLECMLN | RLAGIRDFKQ | ||||
GRHLLTVLLK | LFSYCVKVKV | NRQQLVKLEM | NTLNVMLGTL | NLALVAEQES | ||||
KDSGGAAVAE | QVLSIMEIIL | DESNAEPLSE | DKGNLLLTGD | KDQLVMLLDQ | ||||
INSTFVRSNP | SVLQGLLRII | PYLSFGEVEK | MQILVERFKP | YCNFDKYDED | ||||
HSGDDKVFLD | CFCKIAAGIK | NNSNGHQLKD | LILQKGITQN | ALDYMKKHIP | ||||
SAKNLDADIW | KKFLSRPALP | FILRLLRGLA | IQHPGTQVLI | GTDSIPNLHK | ||||
LEQVSSDEGI | GTLAENLLEA | LREHPDVNKK | IDAARRETRA | EKKRMAMAMR | ||||
QKALGTLGMT | TNEKGQVVTK | TALLKQMEEL | IEEPGLTCCI | CREGYKFQPT | ||||
KVLGIYTFTK | RVALEEMENK | PRKQQGYSTV | SHFNIVHYDC | HLAAVRLARG | ||||
REEWESAALQ | NANTKCNGLL | PVWGPHVPES | AFATCLARHN | TYLQECTGQR | ||||
EPTYQLNIHD | IKLLFLRFAM | EQSFSADTGG | GGRESNIHLI | PYIIHTVLYV | ||||
LNTTRATSRE | EKNLQGFLEQ | PKEKWVESAF | EVDGPYYFTV | LALHILPPEQ | ||||
WRATRVEILR | RLLVTSQARA | VAPGGATRLT | DKAVKDYSAY | RSSLLFWALV | ||||
DLIYNMFKKV | PTSNTEGGWS | CSLAEYIRHN | DMPIYEAADK | ALKTFQEEFM | ||||
PVETFSEFLD | VAGLLSEITD | PESFLKDLLN | SVP |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000127481 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066036 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (Dec 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- ^ Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722.
- ^ "Entrez Gene: ZUBR1 zinc finger, UBR1 type 1".
- ^ "UniProt, Q5T4S7" (jezik: eng.). Pristupljeno 1. 12. 2021.CS1 održavanje: nepoznati jezik (link)
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