CHMP4C

CHMP4C
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3C3R
Identifikatori
Aliasi	CHMP4C
Vanjski ID-jevi	OMIM: 610899 MGI: 1913621 HomoloGene: 23544 GeneCards: CHMP4C
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	81,759,515 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	10,493,916 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • ESCRT III complex; • citosol; • endozom; • membrana; • late endosome membrane; • midbody; • Flemming body;
Biološki proces	• regulation of centrosome duplication; • abscission; • viral budding via host ESCRT complex; • GO:0019067 viral life cycle; • nucleus organization; • multivesicular body assembly; • regulation of mitotic spindle assembly; • endosomal transport; • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; • protein transport; • negative regulation of cytokinesis; • septum digestion after cytokinesis; • mitotic metaphase plate congression; • vacuolar transport; • macroautophagy; • mitotic cytokinesis checkpoint signaling; • midbody abscission;
	Izvori:Amigo / QuickGO
Ortolozi
	92421
	66371
	ENSG00000164695
	ENSMUSG00000027536
	Q96CF2
	Q9D7F7
	NM_152284
	NM_025519
	NP_689497
	NP_079795
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Naelektrizirani multivezikulski tjelesni protein 4c je protein koji je kod ljudi kodiran genom CHMP4C.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 233 aminokiseline, а molekulska težina 26.411 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSKLGKFFKG	GGSSKSRAAP	SPQEALVRLR	ETEEMLGKKQ	EYLENRIQRE
IALAKKHGTQ	NKRAALQALK	RKKRFEKQLT	QIDGTLSTIE	FQREALENSH
TNTEVLRNMG	FAAKAMKSVH	ENMDLNKIDD	LMQEITEQQD	IAQEISEAFS
QRVGFGDDFD	EDELMAELEE	LEQEELNKKM	TNIRLPNVPS	SSLPAQPNRK
PGMSSTARRS	RAASSQRAEE	EDDDIKQLAA	WAT

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164695 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027536 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
^ Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
^ "Entrez Gene: CHMP4C chromatin modifying protein 4C".
^ "UniProt, Q96CF2" (jezik: engleski). Pristupljeno 15. 9. 2021.

Dopunska literatura uredi

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

Vanjski linkovi uredi

Lokacija ljudskog genoma CHMP4C i stranica sa detaljima o genu CHMP4C u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164695 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027536 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12860994-5] Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.

[pmid14678797-6] Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.

[entrez-7] "Entrez Gene: CHMP4C chromatin modifying protein 4C".

[UniProt-8] "UniProt, Q96CF2" (jezik: engleski). Pristupljeno 15. 9. 2021.

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