CC motivni hemokin 11, znan i kao eozinofilni
hemo-
taksijski protein

i eotaksin-1 je protein koji je kod ljudi kodiran genom CCL11. Ovaj gen ima tri egzona i nalazi se na hromosomu 17.[5][6]

CCL11
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1EOT, 2EOT, 2MPM

Identifikatori
AliasiCCL11
Vanjski ID-jeviOMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za CCL11
Genomska lokacija za CCL11
Bend17q12Početak34,285,742 bp[1]
Kraj34,288,334 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za CCL11
Genomska lokacija za CCL11
Bend11 C|11 49.84 cMPočetak81,948,649 bp[2]
Kraj81,953,781 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija cytokine activity
GO:0001948, GO:0016582 protein binding
chemokine activity
CCR3 chemokine receptor binding
protein dimerization activity
receptor ligand activity
CCR chemokine receptor binding
Ćelijska komponenta extracellular region
Vanćelijsko
intracellular anatomical structure
Biološki proces G protein-coupled receptor signaling pathway
positive regulation of endothelial cell proliferation
positive regulation of actin filament polymerization
response to interleukin-4
branching involved in mammary gland duct morphogenesis
monocyte chemotaxis
actin filament organization
positive regulation of cell migration
chemokine-mediated signaling pathway
response to interleukin-13
cellular response to tumor necrosis factor
response to virus
cellular calcium ion homeostasis
mast cell chemotaxis
neutrophil chemotaxis
positive regulation of angiogenesis
mammary duct terminal end bud growth
Hemotaksija
protein phosphorylation
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
Ćelijska adhezija
cytoskeleton organization
cellular response to interleukin-1
GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
positive regulation of ERK1 and ERK2 cascade
regulation of cell shape
cellular response to interferon-gamma
lymphocyte chemotaxis
response to radiation
inflammatory response
chronic inflammatory response
GO:0072468 Transdukcija signala
eosinophil chemotaxis
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
cytokine-mediated signaling pathway
ERK1 and ERK2 cascade
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_002986

NM_011330

RefSeq (bjelančevina)

NP_002977

NP_035460

Lokacija (UCSC)Chr 17: 34.29 – 34.29 MbChr 11: 81.95 – 81.95 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Sekvenca

Simboli

Dužina peptidnog lanca je 97
aminokiselina,
a molekulska težina 10.732 Da.[7]

1020304050
MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYR
RITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP

Funkcija uredi

CCL11 je mali citokin koji pripada porodici CC hemokina. CCL11 selektivno regrutuje eozinofile, inducirajući njihovu hemotaksiju, te je zato upleten u alergijske odgovore.[8][9][10] Efekti CCL11 posreduju se njegovim vezanjem na receptor povezan sa G-proteinima, poznat kao hemokinski receptor. Hemokinski receptori za koje je CCL11 ligand uključuju CCR2,[11] CCR3[5] i CCR5.[11] Međutim, utvrđeno je da eotaksin-1 (CCL11) ima visok stepen selektivnosti za svoj receptor, tako da je neaktivan na neutrofil imai monocitima, koji ne eksprimiraju CCR3.[12]

Klinički značaj uredi

Povećani nivoi CCL11 u krvnoj plazmi povezani su sa starenjem miševa i ljudi.[13] Pored toga, pokazano je da izlaganje mladih miševa CCL11-u ili krvnoj plazmi starijih miševa smanjuje njihovu neurogenezu i kognitivne performanse na ponašanje za koje se smatra da ovise o neurogenezi u hipokampusu.[13]

U sadašnjih korisnika kanabisa utvrđene su veće koncentracije CCL11 u plazmi, u odnosu na ranije korisnike i one koji nikada nisu koristili. CCL11 je također pronađen u većim koncentracijama kod ljudi koji pate od shizofrenije; kanabis je poznati pokretač shizofrenije.[14]

Također je biomarker za CTE ili sindroma opojnog udara.[15]

Tokom upala kostiju, CCL11 i CCR3 su regulirani. To je povezano s povećanjem aktivnosti osteoklasta.[16]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172156 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020676 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
  6. ^ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
  7. ^ "UniProt, P51671". Pristupljeno 28. 6. 2021.
  8. ^ Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (Mar 1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation". The Journal of Experimental Medicine. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365.
  9. ^ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
  10. ^ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.
  11. ^ a b Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (Apr 2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood. 97 (7): 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.
  12. ^ Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annual Review of Immunology. 15: 675–705. doi:10.1146/annurev.immunol.15.1.675. PMID 9143704.
  13. ^ a b Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. (Sep 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature. 477 (7362): 90–4. doi:10.1038/nature10357. PMC 3170097. PMID 21886162.
  14. ^ Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (Oct 2013). "Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 46: 25–8. doi:10.1016/j.pnpbp.2013.06.011. PMID 23820464. S2CID 207410464.
  15. ^ Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC (2017). "CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease". PLOS ONE. 12 (9): e0185541. doi:10.1371/journal.pone.0185541. PMC 5614644. PMID 28950005. SažetakLabEquipment.
  16. ^ Kindstedt E, Holm CK, Sulniute R, Martinez-Carrasco I, Lundmark R, Lundberg P (juli 2017). "CCL11, a novel mediator of inflammatory bone resorption". Scientific Reports. 7 (1): 5334. doi:10.1038/s41598-017-05654-w. PMC 5509729. PMID 28706221.

Vanjski linkovi uredi

Dopunska literatura uredi