ANGPTL1

ANGPTL1
Identifikatori
Aliasi	ANGPTL1
Vanjski ID-jevi	OMIM: 603874 MGI: 1919963 HomoloGene: 128467 GeneCards: ANGPTL1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	178,871,077 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	156,688,648 bp
Ontologija gena
Molekularna funkcija	• signaling receptor binding;
Ćelijska komponenta	• Egzosom; • extracellular region; • Vanćelijsko;
Biološki proces	• transmembrane receptor protein tyrosine kinase signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	9068
	72713
	ENSG00000116194
	ENSMUSG00000033544
	O95841
	Q640P2
	NM_004673; NM_001376763
	NM_028333
	NP_004664; NP_001363692
	NP_082609
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Angiopoetinu-srodni protein 1, znan i kao angiopoetin-3 (ANG-3) jest protein koji je kod ljudi kodiran genom ANGPTL1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 491 aminokiselina, a molekulska težina 56.720 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKTFTWTLGV	LFFLLVDTGH	CRGGQFKIKK	INQRRYPRAT	DGKEEAKKCA
YTFLVPEQRI	TGPICVNTKG	QDASTIKDMI	TRMDLENLKD	VLSRQKREID
VLQLVVDVDG	NIVNEVKLLR	KESRNMNSRV	TQLYMQLLHE	IIRKRDNSLE
LSQLENKILN	VTTEMLKMAT	RYRELEVKYA	SLTDLVNNQS	VMITLLEEQC
LRIFSRQDTH	VSPPLVQVVP	QHIPNSQQYT	PGLLGGNEIQ	RDPGYPRDLM
PPPDLATSPT	KSPFKIPPVT	FINEGPFKDC	QQAKEAGHSV	SGIYMIKPEN
SNGPMQLWCE	NSLDPGGWTV	IQKRTDGSVN	FFRNWENYKK	GFGNIDGEYW
LGLENIYMLS	NQDNYKLLIE	LEDWSDKKVY	AEYSSFRLEP	ESEFYRLRLG
TYQGNAGDSM	MWHNGKQFTT	LDRDKDMYAG	NCAHFHKGGW	WYNACAHSNL
NGVWYRGGHY	RSKHQDGIFW	AEYRGGSYSL	RAVQMMIKPI	D

Funkcija

Angiopoetini su članovi porodice faktora rasta vaskularnog endotela i jedini poznati faktori rasta koji su uglavnom specifični za vaskularni endotel. Angiopoetin-1, angiopoetin-2 i angiopoetin-4 učestvuju u formiranju krvnih sudova.

Protein kodiran ovim genom je još jedan član porodice angiopoetina koji je široko eksprimiran u tkivima odraslih s najvišim nivoima iRNK u visoko vaskulariziranim tkivima. Utvrđeno je da je ovaj protein sekretorni protein koji ne djeluje kao endotelni mitogen in vitro.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116194 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033544 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi:10.1016/S0014-5793(99)00008-3. PMID 10025962. S2CID 27230019.
^ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
^ ^a ^b "Entrez Gene: ANGPTL1 angiopoietin-like 1".
^ "UniProt, O95841" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS (2005). "Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308–15. doi:10.1016/j.bbrc.2005.05.134. PMID 15950186.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
Kim I, Moon SO, Koh KN, et al. (1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J. Biol. Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220. S2CID 19001234.
Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
Smagur A, Szary J, Szala S (2006). "Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours". Acta Biochim. Pol. 52 (4): 875–9. doi:10.18388/abp.2005_3401. PMID 15940350.

Vanjski linkovi

Lokacija ljudskog genoma ANGPTL1 i stranica sa detaljima o genu ANGPTL1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116194 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033544 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10025962-5] Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi:10.1016/S0014-5793(99)00008-3. PMID 10025962. S2CID 27230019.

[pmid9286704-6] Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.

[entrez-7] "Entrez Gene: ANGPTL1 angiopoietin-like 1".

[UniProt-8] "UniProt, O95841" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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